60847-65-6

Upstream product

• 141-52-6 sodium ethanolate 
• 94-41-7 benzalacetophenone 
• 109-77-3 malononitrile 
• 68196-10-1 1,1-dicyano-2-phenyl-4-phenyl-1,3-butadiene 
• 2700-22-3 Benzylidenemalononitrile 
• 98-86-2 acetophenone 
• 614-47-1 1,3-diphenyl-propen-3-one 
• 100-52-7 benzaldehyde 
• 5447-87-0 2-(1-phenylethylidene)propanedinitrile 
• 94360-09-5 3-benzoyl-1-bromo-2-phenyl-1,1-dicyanopropane 
• 62940-90-3 2-(3-oxo-1,3-diphenylpropyl)malononitrile 
• 64-17-5 ethanol 
• 82127-26-2 2-bromo-4,6-diphenylpyridine-3-carbonitrile 

Relevant academic research and scientific papers

Synthesis of polysubstituted pyridines via reactions of chalcones and malononitrile in alcohols using Amberlite IRA-400 (OH-)

Polysubstituted pyridine derivatives were synthesized through economical one-pot multicomponent reactions of different α,β-unsaturated ketones, malononitrile, and ethanol or methanol in the presence of Amberlite IRA-400 (OH-) at room temperatur

Studies of Polyfunctionally Substituted Heteroaromatics: Synthesis of New Polyfunctionally Substituted Azabiaryls

The styryl derivatives 1a-e reacted with malononitrile by refluxing in ethanolic sodium ethoxide solution to yield the polyfunctionally substituted pyridine derivatives 4a-e rather than 7a-e, respectively.Compounds 4a-k were also obtained via condensation

A Facile Synthesis of 6-Alkoxy-2,4-diaryl-5-cyanopyridine

A new synthesis of substituted pyridine is reported.The base catalyzed reaction of substituted chalcones with malononitrile using sodium ethoxide in ethanol at room temperature afforded 2,4-diaryl-5-cyano-6-ethoxypyridine.Similarly, 2,4-diaryl-5-cyano-6-methoxypyridine have been prepared in presence of sodium methoxide in methanol as a catalyst.

A NOVEL SYNTHETIC ROUTE TO PHENYL-SUBSTITUTED PYRIDINES; SYNTHESIS OF BENZOPYRANOPYRIDINES, BENZOTHIOPYRANOPYRIDINES AND PYRIDOBENZOTHIAZINES(1-AZAPHENOTHIAZINES)

Reaction of 1,3-diphenylpropenone with malononitrile in base affords 1,4-diphenyl-2-methoxypyridine-3-carbonitrile.This reaction has been applied to a general synthesis of phenyl-substituted benzopyranopyridines, benzothiopyranopyridines and pyridobenzothiazines(1-azaphenothiazines).

CYCLIZATION OF NITRILES. IX. SYNTHESES BASED ON 2-ARYL-3-AROYL-1,1-DICYANOPROPANES

2-Aryl-3-aroyl-1,1-dicyanopropanes and 2-aryl-3-aroyl-1-bromo-1,1-dicyanopropanes were synthesized from chalcones and malononitrile and were converted into 4,6-diaryl-2-bromo-3-cyanopyridines and 3-cyano-2(1H)-pyridinethiones.The 2-aryl-3-aroyl-1-bromo-1,1-dicyanopropanes proved convenient intermediates for the production of the corresponding cyclopropanes and other compounds.By their reaction with urea a new method was developed for the production of substituted 3-cyano-2(1H)-pyridinethiones.The 2-bromo-3-cyanopyridines contain a mobile bromine atom readily exchanged for the various nucleophilic residues of alcohols and amines and for iodide, and cyano and thiocyanato groups.The 3-cyano-2(1H)-pyridinethiones were used in the synthesis of 3-aminothienopyridines through the isolated 2-Z-methylthio-3-cyanopyridines.