82128-11-8

Usage

Nitrile derivative

The compound is derived from nitriles, which are molecules containing a triple bond between carbon and nitrogen atoms.

Trifluoromethyl group

The presence of a CF3 group (three fluorine atoms bonded to a carbon atom) contributes to the compound's stability and reactivity.

Building block in organic synthesis

The compound is often used as a starting material or intermediate in the synthesis of more complex organic molecules.

Versatile properties

Due to its unique structure and functional groups, the compound can be used in various chemical reactions and transformations.

Pharmaceutical research

The compound has potential applications in the development of new drugs and therapeutic agents.

Crop protection agents

It may be used in the development of chemicals that protect crops from pests and diseases.

Materials science

The compound's unique structure and properties make it a potential candidate for use in the development of new materials with specific functions or characteristics.

Interesting target for further studies

The compound's structure and functional groups make it an attractive subject for further chemical and pharmaceutical research to explore its potential applications and properties.

Upstream product

• 7677-24-9 trimethylsilyl cyanide 
• 437-81-0 2,6-difluorobenzaldehyde 

Downstream Products

• 82128-12-9 ethyl 1-hydroxy-1-(2,6-difluorophenyl)-methanecarboximidate hydrochloride 
• 82128-13-0 5-(2,6-difluorophenyl)oxazolidine-2,4-dione 
• 82128-26-5 5-(2-fluoro-6-methoxyphenyl)oxazolidine-2,4-dione 
• 100947-70-4 5-[2-fluoro-6-(methylthio)phenyl]oxazolidine-2,4-dione 
• 100947-69-1 5-(2-fluoro-6-isopropoxyphenyl)oxazolidine-2,4-dione 
• 100947-71-5 5-[2-fluoro-6-(ethylthio)phenyl]oxazolidine-2,4-dione 
• 133562-32-0 2-amino-1-(2,6-difluorophenyl)ethanol 
• 251366-91-3 2-(2, 6-difluorophenyl)-2-hydroxyacetamide 

Relevant academic research and scientific papers

SUBSTITUTED PYRIDINES AS INHIBITORS OF DNMT1

The invention is directed to substituted pyridine derivatives. Specifically, the invention is directed to compounds according to Formula (Iar): (Iar) wherein Yar, X1ar, X2ar, R1ar, R2ar, R3ar, R4ar and R5ar are as defined herein; or a pharmaceutically acceptable salt or prodrug thereof. The compounds of the invention are selective inhibitors of DNMT1 and can be useful in the treatment of cancer, pre-cancerous syndromes, beta hemoglobinopathy disorders, sickle cell disease, sickle cell anemia, and beta thalassemia, and diseases associated with DNMT1 inhibition. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting DNMT1 activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.

Isoquinoline-based analogs of the cancer drug clinical candidate tipifarnib as anti-Trypanosoma cruzi agents

We developed a synthetic route to prepare isoquinoline analogs of the cancer drug clinical candidate tipifarnib. We show that these compounds kill Trypanosoma cruzi amastigotes grown in mammalian host cells at concentrations in the low nanomolar range. Th

Hypoglycemic 5-substituted oxazolidine-2,4-diones

Hypoglycemic 5-phenyl and 5-naphthyl oxazolidine-2,4-diones and the pharmaceutically-acceptable salts thereof; certain 3-acylated derivatives thereof; a method of treating hyperglycemic animals therewith; and intermediates useful in the preparation of said compounds.