82128-71-0

Upstream product

• 7677-24-9 trimethylsilyl cyanide 
• 135-02-4 ortho-anisaldehyde 

Downstream Products

• 58681-39-3 ethyl 1-hydroxy-1-(2-methoxyphenyl)methanecarboximidate hydrochloride 
• 87712-80-9 (R,R)-(+)-α-<(1-phenylethyl)amino>-α-(2-methoxyphenyl)acetonitrile hydrochloride 
• 87712-81-0 (S,S)-(-)-α-<(1-phenylethyl)amino>-α-(2-methoxyphenyl)acetonitrile hydochloride 
• 96824-32-7 (S)-(2-Methoxy-phenyl)-((R)-1-phenyl-ethylamino)-acetonitrile; hydrochloride 
• 74552-54-8 2-Hydroxy-2-(2-methoxyphenyl)-1-phenylethanone 
• 121985-99-7 2-hydroxy-2-(2-methoxyphenyl)acetonitrile 
• 177944-23-9 (S)-(-)-α-hydroxy-2-methoxyphenylacetonitrile 
• 121985-99-7 (R)-(+)-α-hydroxy-2-methoxyphenylacetonitrile 
• 40877-17-6 4-chloro-1-(2-methoxyphenyl)-1-butanone 
• 313369-21-0 4-chloro-1-(2-hydroxyphenyl)-1-butanone 
• 82128-72-1 5-(2-methoxyphenyl)oxazolidine-2,4-dione 
• 73867-38-6 2-acetoxy-1-phenyl-2-(2-methoxyphenyl)ethanone 
• 24534-42-7 4-methoxy-2-phenylbenzofuran 

Relevant academic research and scientific papers

A two-dimensional manganese coordination polymer: Crystal structure, proton conductivity and catalytic property

Herein, we report a new Manganese coordination polymer, Mn3L2(H2O)4·2H2O (1), based on the 4′-(1-H-tetrazol-5-yl)-[1,1′-biphenyl]-3,5-dicarboxylic acid (H3L) ligand under solvothermal condi

Application of an Electrochemical Microflow Reactor for Cyanosilylation: Machine Learning-Assisted Exploration of Suitable Reaction Conditions for Semi-Large-Scale Synthesis

Cyanosilylation of carbonyl compounds provides protected cyanohydrins, which can be converted into many kinds of compounds such as amino alcohols, amides, esters, and carboxylic acids. In particular, the use of trimethylsilyl cyanide as the sole carbon source can avoid the need for more toxic inorganic cyanides. In this paper, we describe an electrochemically initiated cyanosilylation of carbonyl compounds and its application to a microflow reactor. Furthermore, to identify suitable reaction conditions, which reflect considerations beyond simply a high yield, we demonstrate machine learning-assisted optimization. Machine learning can be used to adjust the current and flow rate at the same time and identify the conditions needed to achieve the best productivity.

Crystal transformation in Mn(ii) metal-organic frameworks based on a one-dimensional chain precursor

The solvothermal reaction of Mn(ii) salts and 5-((4′-(tetrazol-5′′-yl)benzyl)oxy)isophthalic acid (H3L) affords an Mn(ii) based coordination polymer Mn(H2L)2(H2O)2(1), which possesses a one-dimensiona

Role of metal center and coordination environment in M-(Z)-N-((E)-pyridin-2-ylmethylene)isonicotinohydrazonate (M = LaIII, ZnII, CdII or HgII) catalyzed cyanosilylation of aldehydes

A series of known metal complexes, [LaL2(NO3)(H2O)2]·5H2O (1), [Zn(μ-L)(NO3)(H2O)]n (2), {[Cd2(μ-HL)(μ-L)(NO3)3(H2O)]·Hsub

A novel 3D terbium metal-organic framework as a heterogeneous Lewis acid catalyst for the cyanosilylation of aldehyde

A novel 3D lanthanide(iii) metal-organic framework (MOF) (namely Tb-MOF), was synthesized by self-assembly from Tb(iii) ion nitrate and the rigid organic ligand H2sbdc (H2sbdc = 5,5-dioxo-5H-dibenzo[b,d]thiophene-3,7-dicarboxylic acid), and could work as

Porous Co-MOF for cyanosilylation reaction and protective effect in child bronchial pneumonia by reducing the inflammatory response and IL-12 production in immune cells

A new porous metal–organic framework (MOF) with the chemical formula of [Co2(FDDI)(H2O)3](DMA)4 (1, H4FDDI = 5,5′-(9H-fluorene-2,7-diyl) showing the ttd-type topological structure has been prepared by

Lewis Acid Mediated Nazarov Cyclization as a Convergent and Enantioselective Entry to C-nor-D-homo-Steroids

A straightforward synthesis of C-nor-D-homo steroids starting from (+)-Wieland–Miescher ketone is reported. This convergent synthetic strategy utilizes a?scalable diastereoselective Nazarov cyclization of functionalized chiral aryl vinyl ketones, allowing for further functionalization. The ability to conduct this key transformation on a multi-gram scale paves the way for the synthesis of a variety of completely new C-nor-D-homo steroids, without the need of a classic steran steroid rearrangement or achiral linear reaction sequences.

Metal free mild and selective aldehyde cyanosilylation by a neutral penta-coordinate silicon compound

This study demonstrates the preparation and structural characterization of a Si(iv) hydride (PhC(NtBu)2SiH(CH3)Cl) (1) and its use as a catalyst for the cyanosilylation of a variety of aldehydes. Compound 1 represents the first neutr

Hydroxynitrile Lyase Isozymes from Prunus communis: Identification, Characterization and Synthetic Applications

Biocatalysts originating from Badamu (Prunus communis) have been applied to catalyze the asymmetric synthesis of (R)-4-methylsulfanylmandelonitrile, a key building block of thiamphenicol and florfenicol. Here, four hydroxynitrile lyase (HNL) isozymes from Badamu were cloned and heterologously expressed in Pichia pastoris. The biochemical properties and catalytic performances of these isozymes were comprehensively explored to evaluate their efficiency and selectivity in asymmetric synthesis. Among then, PcHNL5 was identified with outstanding activity and enantioselectivity in asymmetric hydrocyanation. Under the optimized mild biphasic reaction conditions, seventeen prochiral aromatic aldehydes were converted to valuable chiral cyanohydrins with good yields (up to 94%) and excellent optical purities (up to >99.9% ee), which provide a facile access to numerous chiral amino alcohols, hypoglycemic agents, angiotension converting enzyme (ACE) inhibitors and β-blockers. This work therefore underlines the importance of discovering the most potent biocatalyst among a group of isozymes for converting unnatural substrates into value-added products. (Figure presented.).

Solvent-Induced Facile Synthesis of Cubic-, Spherical-, and Honeycomb-Shape Palladium N-Heterocyclic Carbene Particles and Catalytic Applications in Cyanosilylation

The facile synthesis of palladium N-heterocyclic carbene (NHC) particles with spherical, cubic, and honeycomb morphologies is accomplished. The structures of cubic and honeycomb particles are defined as an unprecedented trinuclear palladium-NHC complex. A