Benzeneacetonitrile, 2-methoxy-a-[(trimethylsilyl)oxy]-

Base Information

Chemical Name:Benzeneacetonitrile, 2-methoxy-a-[(trimethylsilyl)oxy]-
CAS No.:82128-71-0
Molecular Formula:C12H17NO2Si
Molecular Weight:235.358
Hs Code.:

Synonyms:2-(2-methoxyphenyl)-2-trimethylsiloxyethanenitrile;(+/-)-o-methoxymandelonitrile trimethylsilyl ether;2-methoxy-α-[(trimethylsilyl)oxy]benzeneacetonitrile;2-(2-methyloxyphenyl)-2-(trimethylsilyloxy)acetonitrile;2-(2-methoxyphenyl)-2-(trimethylsilyloxy)ethanenitrile;

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Benzeneacetonitrile, 2-methoxy-a-[(trimethylsilyl)oxy]-

Chemical Property:

PSA：42.25000
LogP:3.11138

Purity/Quality:

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Technology Process of Benzeneacetonitrile, 2-methoxy-a-[(trimethylsilyl)oxy]-

There total 1 articles about Benzeneacetonitrile, 2-methoxy-a-[(trimethylsilyl)oxy]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 7677-24-9
trimethylsilyl cyanide

: 135-02-4
ortho-anisaldehyde

: 82128-71-0
2-(2-methyloxyphenyl)-2-(trimethylsilyloxy)acetonitrile

Guidance literature:: With tin-tungsten mixed oxide, Sn/W molar ratio = 2, calcined at 800 °C; In 1,2-dichloro-ethane; at 22 - 23 ℃; for 0.5h; Inert atmosphere;
DOI:10.1002/chem.200802536

Reference yield: 89.0%

: 64-17-5
ethanol

: 82128-71-0
2-(2-methyloxyphenyl)-2-(trimethylsilyloxy)acetonitrile

: 58681-39-3
ethyl 1-hydroxy-1-(2-methoxyphenyl)methanecarboximidate hydrochloride

Guidance literature:: With hydrogenchloride; at 5 ℃; for 16h;
DOI:10.1021/jm00155a030

Reference yield: 44.0%

: 109-70-6
1.3-chlorobromopropane

: 82128-71-0
2-(2-methyloxyphenyl)-2-(trimethylsilyloxy)acetonitrile

: 40877-17-6
4-chloro-1-(2-methoxyphenyl)-1-butanone

Guidance literature:: 2-(2-methyloxyphenyl)-2-(trimethylsilyloxy)acetonitrile; With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; at -70 ℃; for 0.5h;

1.3-chlorobromopropane; In tetrahydrofuran; hexane; at 20 ℃; for 2h;

With hydrogenchloride; In methanol; at 20 ℃; Further stages.;
DOI:10.1021/jm020994z