82128-99-2

Upstream product

• 7677-24-9 trimethylsilyl cyanide 
• 447-61-0 2-Trifluoromethylbenzaldehyde 
• 114410-58-1 {Cr(CO)3(C₆H₄(CF₃)CH(CN)OSi(CH₃)3)} 

Downstream Products

• 82129-01-9 5-(2-trifluoromethylphenyl)oxazolidine-2,4-dione 
• 133562-36-4 2-hydroxy-2-[(2-trifluoromethyl)phenyl]ethanamine 
• 100947-90-8 2-Hydroxy-2-(2-trifluoromethyl-phenyl)-acetimidic acid ethyl ester; hydrochloride 

Relevant academic research and scientific papers

Chiral linker. Part 3: Synthesis and evaluation of aryl substituted m-hydrobenzoins as solid supported open chain chiral auxiliaries for the diastereoselective reduction of α-keto esters

Five partly novel aryl substituted m-hydrobenzoins were synthesized and the corresponding desymmetrized hydrobenzoin ethers evaluated as open chain chiral auxiliaries in the L-Selectride mediated stereoselective reduction of phenylglyoxylates, resulting in de values of up to 91%. Two optimized auxiliary structures were immobilized on commercially available Wang-resin and applied as a reusable solid supported chiral auxiliary in the same type of reaction.

Discovery and optimisation of potent, selective, ethanolamine inhibitors of bacterial phenylalanyl tRNA synthetase

High throughput screening of Staphylococcus aureus phenylalanyl tRNA synthetase (FRS) identified ethanolamine 1 as a sub-micromolar hit. Optimisation studies led to the enantiospecific lead 64, a single-figure nanomolar inhibitor. The inhibitor series shows selectivity with respect to the mammalian enzyme and the potential for broad spectrum bacterial FRS inhibition.

Highly Diastereoselective Synthesis of Aminoalcohols of Ephedrine Type

Analogs of ephedrine are obtained in 80percent yield in 3 steps from chiral arenechromium tricarbonyl complexes.Hence optically pure complexes afford optically pure analogs of ephedrine.

Hypoglycemic 5-substituted oxazolidine-2,4-diones

Hypoglycemic 5-phenyl and 5-naphthyl oxazolidine-2,4-diones and the pharmaceutically-acceptable salts thereof; certain 3-acylated derivatives thereof; a method of treating hyperglycemic animals therewith; and intermediates useful in the preparation of said compounds.