82128-99-2

Basic information

• Product Name: 2-(2-trifluoromethylphenyl)-2-trimethylsiloxyethanenitrile
• Synonyms: 2-(2-trifluoromethylphenyl)-2-trimethylsiloxyethanenitrile
• CAS NO: 82128-99-2
• Molecular Weight: 273.33
• Mol File: 82128-99-2.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2-(2-trifluoromethylphenyl)-2-trimethylsiloxyethanenitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-trifluoromethylphenyl)-2-trimethylsiloxyethanenitrile(82128-99-2)
• EPA Substance Registry System: 2-(2-trifluoromethylphenyl)-2-trimethylsiloxyethanenitrile(82128-99-2)

Safety Data

• Hazardous Substances Data: 82128-99-2(Hazardous Substances Data)

Upstream product

• 114410-58-1 {Cr(CO)3(C₆H₄(CF₃)CH(CN)OSi(CH₃)3)} 
• 7677-24-9 trimethylsilyl cyanide 
• 447-61-0 2-Trifluoromethylbenzaldehyde 

Downstream Products

• 82129-01-9 5-(2-trifluoromethylphenyl)oxazolidine-2,4-dione 
• 133562-36-4 2-hydroxy-2-[(2-trifluoromethyl)phenyl]ethanamine 
• 100947-90-8 2-Hydroxy-2-(2-trifluoromethyl-phenyl)-acetimidic acid ethyl ester; hydrochloride 

Relevant articles and documents

Chiral linker. Part 3: Synthesis and evaluation of aryl substituted m-hydrobenzoins as solid supported open chain chiral auxiliaries for the diastereoselective reduction of α-keto esters

Five partly novel aryl substituted m-hydrobenzoins were synthesized and the corresponding desymmetrized hydrobenzoin ethers evaluated as open chain chiral auxiliaries in the L-Selectride mediated stereoselective reduction of phenylglyoxylates, resulting in de values of up to 91%. Two optimized auxiliary structures were immobilized on commercially available Wang-resin and applied as a reusable solid supported chiral auxiliary in the same type of reaction.

Highly Diastereoselective Synthesis of Aminoalcohols of Ephedrine Type

Analogs of ephedrine are obtained in 80percent yield in 3 steps from chiral arenechromium tricarbonyl complexes.Hence optically pure complexes afford optically pure analogs of ephedrine.

Hypoglycemic 5-substituted oxazolidine-2,4-diones

Hypoglycemic 5-phenyl and 5-naphthyl oxazolidine-2,4-diones and the pharmaceutically-acceptable salts thereof; certain 3-acylated derivatives thereof; a method of treating hyperglycemic animals therewith; and intermediates useful in the preparation of said compounds.