82145-52-6

Upstream product

• 82145-51-5 9-(2-Benzoxyethoxymethyl)-1-methylguanine 
• 59277-89-3 acycloguanosine 
• 74-88-4 methyl iodide 
• 82145-24-2 5-Benzamido-4-methylcarbamoylimidazole 
• 82145-32-2 5-Benzamido-1-(2-benzoxyethoxymethyl)-4-methylcarbamoylimidazole 
• 82145-50-4 2-Benzamido-9-(2-benzoxyethoxymethyl)-1-methylpurin-6-one 
• 53525-66-9 4-amino-5-(N-methylcarbamoyl)imidazole 
• 75-09-2 dichloromethane 
• 82145-39-9 5-Amino-1-(2-benzoxyethoxymethyl)-4-methylcarbamoylimidazole 
• 82145-49-1 1-(2-Benzoxyethoxymethyl)-5-(N-benzoyl-S-methylisothiocarbamoyl)amino-4-methylcarbamoylimidazole 
• 82145-48-0 1-(2-Benzoxyethoxymethyl)-5-(N-benzoylthiocarbamoyl)amino-4-methylcarbamoylimidazole 

Relevant academic research and scientific papers

Synthesis and Antiviral Activity of Novel N-Substituted Derivatives of Acyclovir

Novel N-substituted derivatives of acyclovir (1a) were synthesized and evaluated for their antiviral, antimetabolic, and antitumor cell properties in vitro.Monomethylation of 1a at positions 1, 7, and N-2 gave compounds 2-4, respectively.When positions 1 and N-2 were linked together by an isopreno group, the tricyclic 9--1,N-2-isopropenoquanine (5) was obtained.Compound 5 was then further methylated at positions N-2 and 7 to give 6 and 7, respectively.None of the new acyclovir derivatives showed any appreciable antimetabolic or antitumor cell activity.However, compounds 2 and 5 exhibited a marked antiherpetic activity.Their activity spectrum was similar to that of acyclovir, and their selectivity as inhibitors of herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) was at least as great as, if not greater than, that of acylclovir.

N-alkylguanine acyclonucleosides as antiviral agents

Disclosed are compounds of the formula: STR1 and the pharmaceutically acceptable salts thereof wherein R1 and R2 are independently alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl or haloalkynyl, each having 1 to 19 carbon atoms, or R2 is hydrogen; R3 is hydrogen, alkyl having 1 to 6 carbon atoms or hydroxyalkyl having 1 to 6 carbon atoms; R4 is hydrogen, halogen, amino or alkyl having 1 to 4 carbon atoms; R5, R6 and R7 are independently selected from hydrogen, hydroxy, alkyl having 1 to 6 carbon atoms, acyloxy having 1 to 8 carbon atoms, alkoxy having 1 to 6 carbon atoms, hydroxyalkyl having 1 to 6 carbon atoms, acyloxyalkyl having 1 to 12 carbon atoms, amino, alkylamino of 1 to 6 carbon atoms and --PO3=, or two of R5, R6 and R7 taken together form a group --OPO2 O- --, --CH2 OPO2 O- --, --CH2 OPO2 OPO2 O= --, or --OPO2 OPO2 O= --; A is O, S or CH2 and X is a pharmaceutically acceptable anion. The compounds have antiviral activity, especially against viruses of the herpes class.