1-Methylacyclovir

Base Information

Chemical Name:1-Methylacyclovir
CAS No.:82145-52-6
Molecular Formula:C₉H₁₃N₅O₃
Molecular Weight:239.234
Hs Code.:
ChEMBL ID:CHEMBL26744
DSSTox Substance ID:DTXSID60231590
Metabolomics Workbench ID:144519
Wikidata:Q83112524

Synonyms:1-Methylacyclovir;82145-52-6;1-Methyl-9-((2-hydroxyethoxy)methyl)guanine;1-Methyl-9-[(2-hydroxyethoxy)methyl]guanine;CHEMBL26744;SCHEMBL10861011;DTXSID60231590;2-amino-9-(2-hydroxyethoxymethyl)-1-methyl-purin-6-one

Suppliers and Price of 1-Methylacyclovir

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 1-Methylacyclovir

Chemical Property:

Vapor Pressure:1.07E-13mmHg at 25°C
Boiling Point:567°Cat760mmHg
Flash Point:296.7°C
Density:1.61g/cm³
XLogP3:-1.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:239.10183929
Heavy Atom Count:17
Complexity:335

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN1C(=O)C2=C(N=C1N)N(C=N2)COCCO

Technology Process of 1-Methylacyclovir

There total 10 articles about 1-Methylacyclovir which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 82145-51-5
9-(2-Benzoxyethoxymethyl)-1-methylguanine

: 82145-52-6
9-(2-Hydroxyethoxymethyl)-1-methylguanine

Guidance literature:: With sodium; In ammonia;
DOI:10.1002/jhet.5570190104

Reference yield:

: 59277-89-3
acycloguanosine

: 75-09-2
dichloromethane

: 74-88-4
methyl iodide

: 82145-52-6
9-(2-Hydroxyethoxymethyl)-1-methylguanine

Guidance literature:: With NaH; In MeOH-H₂ O; dimethyl sulfoxide;

Reference yield:

: 82145-24-2
5-Benzamido-4-methylcarbamoylimidazole

: 82145-52-6
9-(2-Hydroxyethoxymethyl)-1-methylguanine

Guidance literature:: Multi-step reaction with 7 steps

1: 46 percent / Et₃N / dimethylformamide / 16 h

2: 78 percent / hydrazine hydrate / ethanol / 16 h / Heating

3: acetone / 0.5 h / Heating

4: 82 percent / 0.2N aq. NaOH / 2 h

5: 93 percent / 7N aq. NaOH / dioxane / 6 h / Heating

6: 66 percent / hydrazine hydrate / ethanol / 16 h / Heating

7: 73 percent / Na / liquid ammonia

With sodium hydroxide; sodium; hydrazine hydrate; triethylamine; In 1,4-dioxane; ethanol; ammonia; N,N-dimethyl-formamide; acetone;
DOI:10.1002/jhet.5570190104