82158-22-3Relevant academic research and scientific papers
Copper(I)-Catalyzed Chemoselective Reduction of Benzofuran-2-yl Ketones to Alcohols with B2pin2 via a Domino-Borylation-Protodeboronation Strategy
Xuan, Qingqing,Kong, Weiguang,Song, Qiuling
, p. 7602 - 7607 (2017/07/26)
A novel copper(I)-catalyzed chemoselective reduction of the carbonyls of benzofuran-2-yl ketones over furan rings with B2pin2 has been developed. This reaction proceeded under mild conditions. High valuable secondary alcohol derivatives of benzofurans were obtained in good to excellent yields with a broad substrate scope. The mechanistic studies suggested that a domino-borylation-protodeboronation pathway was involved in this reaction.
A straightforward conversion of aurones to 2-benzoylbenzofurans: Transformation of one class of natural products into another
Yahiaoui, Samir,Peuchmaur, Marine,Boumendjel, Ahcne
, p. 7703 - 7707 (2011/10/12)
The naturally occurring aurones (2-benzylidene-3(2H)-benzofuran-3-ones) can be easily converted to another class of natural products 2-benzoylbenzo[b] furans, via an effective reduction, acid-mediated rearrangement, and oxidation cascade. This easy conver
A concerted synthesis of hydroxychalcones, flavanones and benzo[b]furans through palladium-catalysed reactions
De, Mahuya,Majumdar, Dyuti P.,Kundu, Nitya G.
, p. 665 - 674 (2007/10/03)
A convenient palladium-catalysed procedure for the synthesis of o-hydroxychalcones, flavanones and benzo[b]furans is described where o-iodophenyl acetate was used as a common precursor.
1-[(benzofuran-2-yl)phenylmethyl]-triazoles and -tetrazoles - Potent competitive inhibitors of aromatase
Vinh,Ahmadi,Lopez Delgado,Fernandez Perez,Walters,Smith,Nicholls,Simons
, p. 2105 - 2108 (2007/10/03)
The synthesis of a series of novel 1-[(benzofuran-2-yl)phenylmethyl]- triazoles and -tetrazoles is described. The compounds were tested for human placental aromatase inhibition in vitro, using [1β-3H]androstenedione as the substrate for the aromatase enzyme, the percentage inhibition and IC50 data is included.
Synthesis of aryl 2-benzofuranyl and aryl 2-indolyl carbinols of high enantiomeric purity via palladium-catalyzed heteroannulation of chiral arylpropargylic alcohols
Botta, Maurizio,Summa, Vincenzo,Corelli, Federico,Di Pietro, Giovanna,Lombardi, Paolo
, p. 1263 - 1266 (2007/10/03)
2-Iodophenol and 2-iodo-N-mesylaniline have been reacted with α-arylpropargylic alcohols of high enantiomeric purity under transition-metal catalysis leading to aryl 2-benzofuranyl and aryl 2-indolyl carbinols in good yield and high enantiomeric excess, t
Synthesis and pharmacological study of new calcium antagonists analogues of cinnarizine and flunarizine
Younes, S.,Baziard-Mouysset, G.,Saqui-Sannes, G. de,Stigliani, J. L.,Payard, M.,et al.
, p. 943 - 948 (2007/10/02)
Several phosphonic diethyl esters were synthesized and their calcium antagonistic activity evaluated in vitro.The diethyl phosphonate group was condensed on substituted , , , , and groups.Despite the presence of the diethyl phosphonate moiety and the benzhydrylpiperazinyl group, both present in potent calcium antagonist structures, only 1 of the 19 synthesis compounds exhibited a calcium antagonistic profile. diethyl phosphonate / benzhydryl piperazine / calcium antagonist
