82159-06-6

Usage

Uses

Used in Pharmaceutical Industry:
(5-BENZYLIDENE-4-OXO-2-THIOXO-THIAZOLIDIN-3-YL)-ACETIC ACID is used as a therapeutic agent for the treatment of idiopathic pulmonary fibrosis and scleroderma. Its ability to inhibit TGF-β and target PPAR-gamma makes it a promising candidate for managing these fibrotic and inflammatory conditions.
Used in Research and Development:
In the field of medical research, (5-BENZYLIDENE-4-OXO-2-THIOXO-THIAZOLIDIN-3-YL)-ACETIC ACID is used as a research compound to study its potential effects on various diseases and conditions related to inflammation and fibrosis. This can lead to the development of new treatment strategies and a better understanding of the underlying mechanisms of these conditions.
Used in Drug Development:
(5-BENZYLIDENE-4-OXO-2-THIOXO-THIAZOLIDIN-3-YL)-ACETIC ACID is utilized in the development of new drugs targeting fibrotic and inflammatory conditions. Its favorable pharmacokinetic and safety profiles make it a valuable compound for further research and potential clinical trials.

InChI:InChI=1/C12H15NO3S2/c14-10(15)7-13-11(16)9(18-12(13)17)6-8-4-2-1-3-5-8/h6,8H,1-5,7H2,(H,14,15)/p-1/b9-6-

Upstream product

• 5718-83-2 rhodanine 3-acetic acid 
• 100-52-7 benzaldehyde 

Downstream Products

• 82159-07-7 (5-benzyliden-4-oxo-2-thioxo-thiazolidin-3-yl)-acetic acid ethyl ester 

Relevant academic research and scientific papers

Rhodanineacetic acid derivatives as potential drugs: Preparation, hydrophobic properties and antifungal activity of (5-arylalkylidene-4-oxo-2- thioxo-1,3-thiazolidin-3-yl)acetic acids

Some [(5Z)-(5-arylalkylidene-4-oxo-2-thioxo-1,3-thiazolidin-3-yl)]acetic acids were prepared as potential antifungal compounds. The general synthetic approach to all synthesized compounds is presented. Lipophilicity of all the discussed rhodanine-3-acetic acid derivatives was analyzed using a reversed phase high performance liquid chromatography (RP-HPLC) method. The procedure was performed under isocratic conditions with methanol as an organic modifier in the mobile phase using an end-capped non-polar C18 stationary RP column. The RP-HPLC retention parameter log k (the logarithm of the capacity factor k) is compared with log P values calculated in silico. All compounds were evaluated for antifungal effects against selected fungal species. Most compounds exhibited no interesting activity, and only {(5Z)-[4-oxo-5-(pyridin-2- ylmethylidene)-2-thioxo-1,3-thiazolidin-3-yl]}acetic acid strongly inhibited the growth of Candida tropicalis 156, Candida krusei E 28, Candida glabrata 20/Iand Trichosporon asahii 1188.

Rhodanine derivatives, process for their preparation, and aldose reductase inhibitor containing the rhodanine derivatives as active ingredient

The rhodanine derivatives of the general formula: STR1 wherein (I) R1 and R2 are taken together to represent a tetramethylene or pentamethylene group; (II) R1 represents a hydrogen atom, and R2 represents (1) a