821796-68-3Relevant academic research and scientific papers
Aziridin-2-yl-(aryl) ketone derivative and preparation method thereof
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Paragraph 0056-0060, (2021/08/06)
The invention discloses an aziridin-2-yl-(aryl) ketone derivative and a preparation method thereof, and according to the preparation method, 3-aryl substituted propargyl alcohol, N-protected amine and N-halogenated succinimide are subjected to a multi-step cascade reaction to realize one-pot synthesis of the aziridin-2-yl-(aryl) ketone derivative. The yield of aziridin-2-yl-(aryl) ketone ranges from 70% to 90%, the method has the advantages of being easy to operate, mild in condition, high in yield and the like, and a brand-new synthesis method is provided for derivatives of aziridin-2-yl-(aryl) ketone.
Bi(OTf)3-catalyed One-pot Synthesis of α-Halo-β-amino Ketones and Acyl Aziridines from 3-Aryl Propargyl Alcohols
Zhang, Qinglin,Duan, Yongbin,Guo, Huifeng,Yang, Hong,Zhai, Jiulong,Li, Tiantian,Wang, Zhihai,Lu, Xiaolei,Wang, Yan,Yin, Yan
, p. 1832 - 1838 (2021/06/09)
A Bi(OTf)3-catalyed reaction of 3-aryl propargyl alcohols with sulfonamide and halogen source was firstly investigated, which provided a facile route for the synthesis of a large variety of α-halo-β-amino ketones. The key intermediates, β-amino
Visible-Light Photoredox-Catalyzed Formal [5 + 1] Cycloaddition of N-Tosyl Vinylaziridines with Difluoroalkyl Halides
Liu, Yantao,Luo, Wen,Wang, Zhenjie,Zhao, Yuxin,Zhao, Jingjing,Xu, Xuejun,Wang, Chaojie,Li, Pan
supporting information, p. 9658 - 9664 (2020/12/21)
A visible-light photoredox-catalyzed formal [5 + 1] cycloaddition of N-tosyl vinylaziridines with difluoroalkyl halides as unique C1 synthons was developed. The procedure provides an efficient and practical method to synthesize diverse pyridines in moderate to good yields. The reaction underwent a radical-initiated kinetically controlled ring-opening of vinylaziridines and involved a key α,β-unsaturated imine intermediate, followed by an E2 elimination, a 6πelectrocyclization, and defluorinated aromatization.
Visible-Light-Driven Nitrogen Radical-Catalyzed [3 + 2] Cyclization of Vinylcyclopropanes and N-Tosyl Vinylaziridines with Alkenes
Chen, Jia-Rong,Wu, Ya-Li,Xiao, Wen-Jing,Xu, Shuang-Hua,Zhao, Quan-Qing,Zhou, Xue-Song
, (2020/03/13)
A visible light photoredox-promoted and nitrogen radical catalyzed [3 + 2] cyclization of vinylcyclopropanes and N-tosyl vinylaziridines with alkenes is developed. Key to the success of this process is the use of the readily tunable hydrazone as a nitrogen radical catalyst. Preliminary mechanism studies suggest that the photogenerated nitrogen radical undergoes reversible radical addition to the vinylcyclopropanes and N-tosyl vinylaziridines to enable their ring-opening C-C and C-N bond cleavage and ensuing cyclization with alkenes.
A Bulky Thiyl-Radical Catalyst for the [3+2] Cyclization of N-Tosyl Vinylaziridines and Alkenes
Hashimoto, Takuya,Takino, Kohei,Hato, Kazuki,Maruoka, Keiji
supporting information, p. 8081 - 8085 (2016/09/13)
Thiyl-radical-catalyzed cyclization reactions of N-tosyl vinylaziridines and alkenes were developed as a new synthetic method for the generation of substituted pyrrolidines. The key to making this process accessible to a broad range of substrates is the use of a sterically demanding thiyl radical, which prevents the undesired degradation of the catalyst.
Highly stereoselective samarium(II) iodide-mediated aldol reactions of acylaziridines with aldehydes
Ogawa, Yasuyuki,Kuroda, Kiichi,Mukaiyama, Teruaki
, p. 1309 - 1333 (2007/10/03)
The samarium(II) iodide-mediated stereoselective aldol reactions of acylaziridines with aldehydes are described. β-Amino-β′-hydroxy ketones were synthesized in high yields by the aldol reaction of aldehydes with samarium enolates generated by aziridine-fr
