82257-12-3

Upstream product

• 13534-90-2 dibromo-3,4 pyridine 
• 5188-07-8 sodium thiomethoxide 
• 36953-42-1 3-bromo-4-chloropyridine 
• 82257-10-1 3-Bromo-1H-pyridine-4-thione 
• 74-88-4 methyl iodide 
• 626-55-1 3-Bromopyridine 
• 624-92-0 Dimethyldisulphide 
• 188824-87-5 [4-2H₁]-3-bromopyridine 
• 462-08-8 pyridin-3-ylamine 
• 2402-97-3 3-bromopyridine N-oxide 
• 1678-49-5 3-Bromo-4-nitropyridine N-oxide 

Relevant academic research and scientific papers

SUBSTITUTED QUINOXALINE DERIVATIVES

The present invention relates to substituted quinoxaline derivatives. These compounds are useful for the prevention and/or treatment of several medical conditions including hyperproliferative disorders and diseases.

Unusual t-BuLi induced ortholithiation versus halogen-lithium exchange in bromopyridines: Two alternative strategies for functionalization

The reaction of lithiating agents with various 3-bromopyridines has been investigated. An unprecedented selectivity was observed with t-BuLi, which effected a clean lithiation at C-4. With 3-bromo and 2-chloro-3-bromo pyridines, the ortholithiation-exchange ratio was strongly electrophile and addition order dependent while 2-chloro-5-bromopyridine always gave exclusive C-4 substitution.

The Reaction of Some Halogenated Pyridine Thioethers and Sulphones with Carbon Disulphide

Dithiocarboxylation of some halogenated pyridine sulphones with carbon disulphide and sodium hydride leads to the formation of thiomethyl derivatives via Smiles rearrangement of the initially produced dianion, fragmentation and subsequent methylation.In one instance the pyridino-1,4-dithiine 7 was obtained.The thioether 2d was also converted into a thiomethyl derivative when subjected to the same reaction sequence.