82267-02-5Relevant articles and documents
COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND USE THEREOF AS INHIBITORS OF RAN GTPASE
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Paragraph 0071; 0076; 0091; 0092, (2019/04/09)
Compounds of general formula IA, IB and IC outlined below, including pharmaceutically acceptable salts, solvates and hydrates thereof. Such compounds and pharmaceutical compositions comprising them may be used in medical conditions involving Ran GTPase.
Highly stereoselective synthesis of aryl/heteroaryl-: C -nucleosides via the merger of photoredox and nickel catalysis
Ma, Yingying,Liu, Shihui,Xi, Yifan,Li, Hongrui,Yang, Kai,Cheng, Zhihao,Wang, Wei,Zhang, Yongqiang
supporting information, p. 14657 - 14660 (2019/12/11)
A photoredox/nickel dual-catalyzed decarboxylative cross-coupling reaction of anomeric ribosyl/deoxyribosyl acids with aryl/heteroaryl bromides has been developed. The reaction proceeds smoothly under visible-light irradiation and features the using of cost-effective and easily handled catalysts and starting materials, which allows the highly stereoselective synthesis of diverse aryl/heteroaryl-C-nucleosides in moderate to high yields.
Synthesis of novel C4-linked C2-imidazole ribonucleoside phosphoramidite and its application to probing the catalytic mechanism of a ribozyme
Araki, Lisa,Morita, Keiji,Yamaguchi, Maho,Zhao, Zheng-Yun,Wilson, Timothy J.,Lilley, David M. J.,Harusawa, Shinya
supporting information; experimental part, p. 2350 - 2356 (2009/07/25)
The synthesis of a novel C4-linked C2-imidazole ribonucleoside phosphoramidite (ICN-C2-PA 1) with a two-carbon linker between imidazole and ribose moieties is described. In the phosphoramidite, POM and 2-cyanoethyl groups were select
Synthesis of the first 1,2,4-triazine C-nucleoside and its transformation to novel pyridine C-nucleosides by 'inverse' [4 + 2]-cycloaddition reactions
Richter,Seitz
, p. 175 - 180 (2007/10/02)
The anomeric C-glycosyl precursors 6 and 7, appropriate for C-nucleoside synthesis and functionalized by an imidate group, were prepared. They were utilized as heterodienophiles in a Diels-Alder reaction with inverse electron demand to yield the O-benzyl
Synthesis of C-Nucleosides via Radical Coupling Reaction
Togo, Hideo,Ishigami, Sachiko,Fujii, Misa,Ikuma, Toshihiro,Yokoyama, Masataka
, p. 2931 - 2942 (2007/10/02)
Photolysis of O-acyl derivatives of N-hydroxy-2-thiopyridone, prepared from tetrahydrofuran-2-carboxylic acid, D-ribofuranosylmethanoic acid, and D-ribopyranosylmethanoic acid, gave the corresponding C-nucleoside derivatives in the presence of heteroaromatic compounds via radical pathways.The essential step in this method is a radical coupling reaction of D-ribofuranosyl radical or D-ribopyranosyl radical and some heteroaromatic bases.This is a new method for the preparation of C-nucleosides using sugar carboxylic acids.
Scandium(III) perchlorate (Sc(ClO4)3). A novel catalyst in the α-C- and N-glycosylation reactions
Hachiya,Kobayashi
, p. 3319 - 3320 (2007/10/02)
In the presence of a catalytic amount of scandium(III) perchlorate (Sc(ClO4)3), 1-O-acetyl-2,3,5-tri-O-benzyl-β-D-ribofuranose reacted with trimethylsilylated nucleophiles to afford the corresponding α-D-ribofuranosides in high yield
Stereoselective 1,2-cis Glycosylation Reaction of 1-O-Acetylribose with Silylated Nucleophiles by the Promotion of a New Catalyst System
Mukaiyama, Teruaki,Shimpuku, Tetsuro,Takashima, Tohru,Kobayashi, Shu
, p. 145 - 148 (2007/10/02)
1,2-cis-Ribofuranosides are stereoselectively prepared in high yields by the reaction of 1-O-acetyl-β-D-ribose with silylated nucleophiles by the promotion of a new catalyst system, the combined use of a catalytic amount of tin(IV) chloride and tin(II) tr
4-AMINO-3-(2,3,5-TRI-O-BENZYL-β-D-RIBOFURANOSYL)-5-PYRAZOLECARBONITRILE. SYNTHESIS AND CONVERSION INTO A SUGAR-BLOCKED 5,7-DISUBSTITUTED FORMYCIN ANALOG
Rosowsky, Andre,Ghoshal, Mitali,Solan, Vishnu C.
, p. 47 - 58 (2007/10/02)
The title compound, a potential intermediate to protected C-nucleoside analogs related to formycin A, was synthesized via a new route wherein 2,3,5-tri-O-benzyl-1-O-(p-nitrophenyl)-D-ribofuranose was converted to 2,5-anhydro-3,4,6-tri-O-benzyl-D-allonic a
A CONVENIENT SYNTHESIS OF C-α-D-RIBOFURANOSYL COMPOUNDS FROM 1-O-ACETYL-2,3,5-TRI-O-BENZYL-β-D-RIBOSE BY THE PROMOTION OF TRIPHENYLMETHYL PERCHLORATE
Mukaiyama, Teruaki,Kobayashi, Shu
, p. 81 - 88 (2007/10/02)
In the presence of a catalytic amount of triphenylmethyl perchlorate (trityl perchlorate), 1-O-acetyl-2,3,5-tri-O-benzyl-β-D-ribose stereoselectively reacted with trimethylsilyl nucleophiles, such as trimethylsilyl enol ether, allylsilane, and trimethylsi
A FACILE SYNTHESIS OF Α-C-RIBOFURANOSIDES FROM 1-O-ACETYL RIBOSE IN THE PRESENCE OF TRITYL PERCHLORATE
Mukaiyama, Teruaki,Kobayashi, Shu,Shoda, Shin-ichiro
, p. 1529 - 1530 (2007/10/02)
In the presence of a catalytic amount of trityl perchlorate, 1-o-acetyl ribose stereoselectively reacts with silylated nucleophiles, such as silyl enol ether, allylsilane, and trimethylsilyl cyanide, to give the corresponding α-C-ribofuranosides in excell
