82268-15-3

Usage

Uses

Used in Pharmaceutical Industry:
3-Methyl-5-(pyrrolidin-3-yl)-1,2,4-oxadiazolidine is used as a potential pharmaceutical agent for the development of treatments targeting various diseases and disorders. Its unique structure, including the 1,2,4-oxadiazolidine and pyrrolidine rings, along with the methyl and pyrrolidin-3-yl groups, is believed to enhance its biological activity, making it a promising candidate for further research and development in medicinal chemistry.
Research on 3-Methyl-5-(pyrrolidin-3-yl)-1,2,4-oxadiazolidine and its related compounds is ongoing to explore their full potential in the pharmaceutical field, with the aim of discovering new therapeutic agents that can address unmet medical needs.

InChI:InChI=1/C7H15N3O/c1-5-9-7(11-10-5)6-2-3-8-4-6/h5-10H,2-4H2,1H3

Upstream product

• 917-64-6 methyl magnesium iodide 
• 61821-86-1 (R)-2,2-dimethyl-1,3-dioxolan-4-yl methyl ketone 
• 52373-72-5 methyl (R)-2,2-dimethyl-1,3-dioxolane-4-carboxylate 
• 75-16-1 methylmagnesium bromide 
• 102563-44-0 (R)-2,2-Dimethyl-4-dimethylaminocarbonyl-1,3-dioxolane 
• 917-54-4 methyllithium 
• 110548-95-3 evoxine 
• 77-76-9 2,2-dimethoxy-propane 

Downstream Products

• 77522-15-7 (2R)-2,3-dihydroxy-3-methylbutan-1-yl p-toluenesulfonate 

Relevant academic research and scientific papers

d- and l-Serine, useful synthons for the synthesis of 24-hydroxyvitamin D3 metabolites. A formal synthesis of 1α,24R,25-(OH)3-D3, 24R,25-(OH)2-D3 and 24S,25-(OH)2-D3

d- and l-Serine have been used for the enantioselective synthesis of tosylates 7a and 7b, useful building blocks for the synthesis of triols 5a and 5b which have already been obtained via a diastereoselective synthesis and used for the synthesis of 2a, 2b and 2c. We have thus performed a formal synthesis of 24S,25-(OH)2-D3, 24R,25-(OH)2-D3 and 1α,24R,25-(OH)3-D3.

Synthesis, structure and stereochemistry of quinoline alkaloids from Choisya ternata

A range of seventeen quinoline alkaloids, involving several types of oxidations during their biosynthetic pathways, have been isolated from leaves of Choisya ternata. In addition to the nine known quinoline alkaloids, eight new members of the furoquinoline family, derived mainly from prenylation at C-5 (including two novel hydroperoxides), have been identified. The absolute configurations and enantiopurity values of all chiral quinoline alkaloids have been determined. One of the isolated alkaloids, 7-isopentenyloxy-γ- fagarine, has been used as a precursor for the chemical asymmetric synthesis of the enantiopure alkaloids: evoxine, anhydroevoxine and evodine. The possible roles of oxygenase and other oxygen-atom-transfer enzymes, in the biosynthetic pathways of the C. ternata alkaloids, have been discussed. This journal is The Royal Society of Chemistry.

PYRIMIDINE SULPHONAMIDE DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS

A compound of formula (1), or a pharmaceutically acceptable salt, solvate or in vivo hydrolysable ester thereof and pharmaceutical compositions comprising these, all for use in the treatment of chemokine mediated diseases and disorders.

A Useful Preparation of O-protected α-Hydroxyketones of Defined Enantiomeric Purity from 2-Hydroxyalkanoic Esters

α-Hydroxyketones (OH-protected) are prepared in high enantiomeric purity by reaction of chiral O-protected 2-hydroxyalkanoic esters with organolithium compounds in ether/pentane at -100 deg C or by conversion of 2-hydroxyalkanoic esters into 2-hydroxy-N,N-dimethylalkanamides, O-protection of these amides, and reaction with organomagnesium bromides in tetrahydrofuran/ether at 5 deg C.

Process for the preparation of cholesterol derivatives and novel intermediates therefor

The invention is concerned with a process for the preparation of 1 hydrogen or hydroxy cholesterol derivatives and intermediates therefor. The compounds of the present invention are useful as intermediates in the preparation of 24,25-dihydroxy and 1α, 24,25-trihydroxycholecalciferol.

Synthesis and Determination of the Enantiomeric Pyrity of (R)- and (S)-2,3-Dihydroxy-3-methylbutyl p-Toluensulfonate

(R)- and (S)-2,3-dihydroxy-3-methylbutyl p-toluenesulfonate, used as building blocks for vitamine D3 metabolites and carotenoids, respectively, were resynthesized since differing melting points and optical rotations are reported in the literature.The give

Optically Active C5-Synthons for the Synthesis of Naturally Occurring Terpenes

The optically active synthons (S)-22, (R)-23, (R)-25 and (R)-26 were prepared from L-serine.Furthermore the tertiary alcohol 6 was synthesized from L-serine (-> (S)-6) and D-mannitol (-> (R)-6).These compounds are suitable for the synthesis of optically active natural products.