61821-86-1

Upstream product

• 917-54-4 methyllithium 
• 52373-72-5 methyl (R)-2,2-dimethyl-1,3-dioxolane-4-carboxylate 
• 75-16-1 methylmagnesium bromide 
• 102563-44-0 (R)-2,2-Dimethyl-4-dimethylaminocarbonyl-1,3-dioxolane 
• 60456-21-5 methyl (4S)-2,2-dimethyl-1,3-dioxolane-4-carboxylate 

Downstream Products

• 82268-15-3 2-<(R)-2,2-dimethyl-1,3-dioxolane-4-yl>-2-propanol 
• 180839-80-9 (3R,4S)-1-Benzyl-3-benzyloxy-4-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-4-methyl-azetidin-2-one 
• 192764-16-2 (R)-N-benzyl-1-[(S)-2,2-dimethyl-1,3-dioxolan-4-yl]ethanamine 
• 192764-17-3 (S)-N-benzyl-1-[(S)-2,2-dimethyl-1,3-dioxolan-4-yl]ethanamine 
• 1186333-15-2 2-chloro-5-{7-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]-2-pyridin-4-ylpyrazolo[1,5-a]pyrimidin-3-yl}phenol 
• 117770-24-8 1-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-2-methoxy-2-phenylsulfanyl-ethanone 
• 117770-39-5 (R)-4-[Furan-3-yl-(4-methoxy-benzyloxy)-methyl]-2,2-dimethyl-[1,3]dioxolane 
• 361482-92-0 (+)-(4S)-2,2-Dimethyl-4-[(E)-1,2-dimethyl-3-phenylsulfonylprop-1-enyl]-1,3-dioxolane 
• 361482-93-1 (-)-(4S)-2,2-Dimethyl-4-[(Z)-1,2-dimethyl-3-phenylsulfonylprop-1-enyl]-1,3-dioxolane 
• 180839-79-6 (S)-N-(1-(2,2-dimethyl-1,3-dioxolan-4-yl)ethylidene)-1-phenylmethanamine 
• 77151-50-9 1-deoxy-2-C-ethyl-3,4-O-isopropylidene-D-erythritol 
• 77152-60-4 (S)-2-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-butan-2-ol 
• 117770-30-6 (1RS,2RS,3S)-3,4-O-isopropylidenedioxy-1-methoxy-1-phenylthio-2,3,4-butanetriol 

Relevant academic research and scientific papers

A Useful Preparation of O-protected α-Hydroxyketones of Defined Enantiomeric Purity from 2-Hydroxyalkanoic Esters

α-Hydroxyketones (OH-protected) are prepared in high enantiomeric purity by reaction of chiral O-protected 2-hydroxyalkanoic esters with organolithium compounds in ether/pentane at -100 deg C or by conversion of 2-hydroxyalkanoic esters into 2-hydroxy-N,N-dimethylalkanamides, O-protection of these amides, and reaction with organomagnesium bromides in tetrahydrofuran/ether at 5 deg C.

ON THE SYNTHESIS AND ENANTIOMERIC PYRITY OF (S)-4-ACETYL-2,2-DIMETHYL-1,3-DIOXOLANE

The title ketone has been synthesised in 96percent e.e. from the corresponding methyl ester and MeLi.The D value for the product was considerably higher than values previously reported for the enantiomer.