82295-08-7Relevant articles and documents
Copper-Catalyzed Tertiary Alkylative Cyanation for the Synthesis of Cyanated Peptide Building Blocks
Miwa, Naoki,Tanaka, Chihiro,Ishida, Syo,Hirata, Goki,Song, Jizhou,Torigoe, Takeru,Kuninobu, Yoichiro,Nishikata, Takashi
supporting information, p. 1692 - 1697 (2020/02/04)
In this paper, we report efficient cyanation of various peptides containing the α-bromocarbonyl moiety using a Cu-catalyzed radical-based methodology employing zinc cyanide as the cyanide source. Mechanistic studies revealed that in situ formed CuCN was a key intermediate during the catalytic cycle. Our method could be useful for the synthesis of modified peptides containing quaternary carbons.