82315-66-0

Upstream product

• 5315-25-3 2-bromo-6-methylpyridine 
• 274-59-9 triazolopyridine 
• 77134-17-9 7-lithiotriazolopyridine 
• 34160-40-2 6-bromo-2-pyridinecarbaldehyde 
• 100-97-0 hexamethylenetetramine 
• 626-05-1 2,6-Dibromopyridine 
• 1824-81-3 2-Amino-6-methylpyridine 

Downstream Products

• 34160-40-2 6-bromo-2-pyridinecarbaldehyde 

Relevant academic research and scientific papers

2 - Bromo -6 - aldehyde pyridine and its preparation method

The present invention provides a 2 - bromo - 6 - aldehyde pyridine and its preparation, wherein the preparation method comprises the following steps: step S1, in the 2 - bromo - 6 - methyl pyridine in an organic solution to react [...], generating 2 - bromo - 6 - bromo pyridine and 2 - bromo - 6 - ([...]) pyridine mixture; step S2, adding ethanol in the mixture, and wherein add hexamine, allowing the mixture to react, to obtain 2 - bromo - 6 - formyl pyridine; step S3, after the addition of an acid in the reaction system, make it undergo hydrolytic reaction, generating the 2 - bromo - 6 - aldehyde pyridine. According to the embodiment of the invention of 2 - bromo - 6 - aldehyde pyridine of the preparation method, can obtain a high purity of the product, and the method is safe, easy to process, the process is simple, and is suitable for industrial production.

The expedient access to bromo-pyridine carbaldehyde scaffolds using gem-dibromomethyl intermediates

A simple, efficient, and general two-step synthesis to bromo-pyridine carbaldehyde scaffolds is described. This direct route involves sequential reactions employing the dibromination of bromo-picolines followed by hydrolysis using an aqueous solution of calcium carbonate. Bromo-pyridine carbaldehyde scaffolds 1-7 were obtained in good overall yield. Bromo-dibromomethyl-pyridine intermediates have been isolated and characterized.

Alternative approach to the free radical bromination of oligopyridine benzylic-methyl group

We have undertaken a study on the influence of three solvents on the photobromination of two picolines. It shows that dichloromethane and benzene are better solvents than the classical carbon tetrachloride. The obtention of a good free radical bromination is described using aqueous biphasic media.

Reduced-symmetry Deep-cavity Cavitands

Formula presented The syntheses of reduced-symmetry deep-cavity cavitands by two-stage stereoselective bridging with substituted benzal bromides is reported. Conditions for the optimal formation of the trisbridged derivatives were readily established. However, it was not possible to determine conditions which selectively promoted formation of either one of the two bisbridged species, or the monobridged compound, above the other products. A comparison of yields for A/B bisbridged derivatives verses A/C bisbridged derivatives may indicate that the one-pot formation of deep-cavity cavitands occurs primarily through the former species.

Ligands containing alternating 2,6-linked pyridine and 2,5-linked thiophene units

A variety of linear assemblies of alternating pyridine (2,6-linked) [P] and thiophene (2,5-linked) [T] units have been generated with up to seven units and their macrocyclisation investigated. The optimal methods involved the palladium(0) catalysed reaction of thienyl Grignard reagents with bromopyridines. In this way were made TPT, TPTPT, TPTPTPT, BrPTPBr and various XCH2PTPTPCH2X derivatives (X = H, Br, OH, OR and SBu-t). Alternative routes whereby pyridine units were 2,6-linked by CH2SCH2 units, with the intention of converting the bridge groups into thiophenes by a Hinsberg reaction, were also studied. The latter products {(HOCH2[P]CH2)2S and (HOCH2[P]-CH2SCH2)2[P]} proved to be highly effective ligands for transition metals, especially divalent ones such as Co2+, Ni2+ and Zn2+. No macrocyclisations were effective.

Synthesis of new tetradentate ligands containing both 2,2'-bipyridine and 3-pyridyl-1,2,4-triazine moieties

The synthesis of three new tetradentate ligands containing both 2.2'-bipyridine and 1,2,4-triazine subunits bridged by an ethyl chain is reported.

NUCLEOPHILIC SUBSTITUTIONS ON BROMOTRIAZOLOPYRIDINES - AN IMPROVED ROUTE TO 2,6-DISUBSTITUTED PYRIDINES AND TO 1,3-DISUBSTITUTED ISOQUINOLINES

A regiospecific synthesis of 2,6-disubstituted pyridines and of 1,3-disubstituted isoquinolines is described.

Triazolopyridines. Part 2. Preparation of 7-Substituted Triazolopyridines by Directed Lithiation

The lithiation reactions of 1,2,3-triazolopyridine (1) to give the 7-lithio-derivative (4; R = Li), and of its 7-methyl derivative (16) to give the 7-lithiomethyl compound, are described.These lithium derivatives react with electrophiles, notably a