823219-98-3Relevant academic research and scientific papers
ISOXAZOLES AS PEPTIDE DEFORMYLASE INHIBITORS
-
Page/Page column 24; 33, (2010/02/11)
Isoxazole compounds of formula (I) and pharmaceutically acceptable salts or esters thereof are peptide deformylase inhibitors useful in the treatment or prevention of infections and other disease in which peptide deformylases are involved, especially in t
Isoxazole-3-hydroxamic acid derivatives as peptide deformylase inhibitors and potential antibacterial agents
Calí, Patrizia,N?rum, Lars,Mukhija, Seema,Hjelmencrantz, Anders
, p. 5997 - 6000 (2007/10/03)
The synthesis and initial in vitro evaluation of isoxazole-3-hydroxamic acid derivatives as a new class of PDF inhibitors are reported. A series of isoxazole-3-hydroxamic acid derivatives has been identified as a new class of small, nonpeptidic inhibitors of peptide deformylase (PDF). The synthesis, enzyme inhibition and preliminary investigation of the binding mode of this potential antibacterial compounds are reported.
