823221-94-9

Usage

Uses

Used in Pharmaceutical Industry:
2-Bromo-6-chloro-4-(trifluoromethyl)pyridine is used as an intermediate in the production of various medical drugs. Its unique chemical structure allows it to be a key component in the synthesis of pharmaceutical compounds, contributing to the development of new medications.
Used in Chemical Industry:
2-Bromo-6-chloro-4-(trifluoromethyl)pyridine is used as a catalyst in a number of chemical reactions. Its properties enable it to facilitate and enhance the efficiency of various chemical processes, making it a valuable asset in the synthesis of different compounds.

Upstream product

• 401892-47-5 5-bromo-4-iodo-2-chloropyridine 
• 53939-30-3 5-bromo-2-chloropyridine 
• 823221-93-8 5-bromo-2-chloro-4-(trifluoromethyl)pyridine 

Relevant academic research and scientific papers

Logistic flexibility in the preparation of isomeric halopyridinecarboxylic acids

Although there are many conceivable ways to funtionalize, and specifically carboxylate, 2-chloro-4-(trifluoromethyl)pyridine optionally at all three vacant positions, it is more straightforward to prepare only the 2-chloro-4- (trifluoromethyl)pyridine-3-carboxylic acid (1) from this precursor and the other 6-chloro-4-(trifluoromethyl)pyridine-2- and -3-carboxylic acids (2 and 3) from a different one, viz. 5-bromo-2-chloro-4-(trifluoromethyl)pyridine. In the same manner, it proved more convenient to convert 5-chloro-2-(trifluoromethyl) pyridine in only two of the corresponding acids (6 and 7) and to make the third one (8) from 3-bromo-5-chloro-2-(trifluoromethyl)pyridine as an alternative starting material. All model substrates for functionalization were readily accessible from the correspondingly substituted chloroiodopyridine through heavy halogen displacement by in situ generated (trifluoromethyl)copper. Graphical Abstract