823221-95-0

Basic information

• Product Name: Pyridine, 5-chloro-4-iodo-2-(trifluoroMethyl)-
• Synonyms: Pyridine, 5-chloro-4-iodo-2-(trifluoroMethyl)-;5-Chloro-4-iodo-2-;5-chloro-4-iodo-2-(trifluoroMethyl)pyridine
• CAS NO: 823221-95-0
• Molecular Formula: C₆H₂ClF₃IN
• Molecular Weight: 307.4394596
• EINECS: -0
• Mol File: 823221-95-0.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: Pyridine, 5-chloro-4-iodo-2-(trifluoroMethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyridine, 5-chloro-4-iodo-2-(trifluoroMethyl)-(823221-95-0)
• EPA Substance Registry System: Pyridine, 5-chloro-4-iodo-2-(trifluoroMethyl)-(823221-95-0)

Safety Data

• Hazardous Substances Data: 823221-95-0(Hazardous Substances Data)

Usage

General Description

"Pyridine, 5-chloro-4-iodo-2-(trifluoromethyl)-" is a specific type of pyridine, which is a basic heterocyclic organic compound. Its structure includes a six-member ring with five carbon atoms and one nitrogen atom. As denoted by its name, this chemical compound is characterized by the addition of a chlorine atom at position 5, an iodine atom at position 4, and a trifluoromethyl group at position 2 of the pyridine ring. The inclusion of these halogens and the trifluoromethyl group can significantly alter the compound's properties, potentially making it useful in a variety of scientific and industrial applications. It can play a significant role in drug discovery and material sciences due to its reactivity and structural attributes.

Upstream product

• 244221-57-6 5-chloro-2-iodo-pyridine 
• 40473-01-6 2-Bromo-5-chloro-pyridine 
• 349-94-0 5-chloro-2-(trifluoromethyl)pyridine 

Relevant articles and documents

BICYCLIC UREAS AND THIADIAZOLIDINE-1,1-DIOXIDES AS CETP INHIBITORS

Compounds having the structure of Formula I, including pharmaceutically acceptable salts of the compounds, wherein X is -C(=O) or -S(O)2-, are CETP inhibitors and are useful for raising HDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis.

Logistic flexibility in the preparation of isomeric halopyridinecarboxylic acids

Although there are many conceivable ways to funtionalize, and specifically carboxylate, 2-chloro-4-(trifluoromethyl)pyridine optionally at all three vacant positions, it is more straightforward to prepare only the 2-chloro-4- (trifluoromethyl)pyridine-3-carboxylic acid (1) from this precursor and the other 6-chloro-4-(trifluoromethyl)pyridine-2- and -3-carboxylic acids (2 and 3) from a different one, viz. 5-bromo-2-chloro-4-(trifluoromethyl)pyridine. In the same manner, it proved more convenient to convert 5-chloro-2-(trifluoromethyl) pyridine in only two of the corresponding acids (6 and 7) and to make the third one (8) from 3-bromo-5-chloro-2-(trifluoromethyl)pyridine as an alternative starting material. All model substrates for functionalization were readily accessible from the correspondingly substituted chloroiodopyridine through heavy halogen displacement by in situ generated (trifluoromethyl)copper. Graphical Abstract