82340-98-5

Basic information

• Product Name: Benzeneacetic acid, 3-(2-nitrophenoxy)-, methyl ester
• CAS NO: 82340-98-5
• Molecular Formula: C15H13NO5
• Molecular Weight: 287.272
• Mol File: 82340-98-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Benzeneacetic acid, 3-(2-nitrophenoxy)-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzeneacetic acid, 3-(2-nitrophenoxy)-, methyl ester(82340-98-5)
• EPA Substance Registry System: Benzeneacetic acid, 3-(2-nitrophenoxy)-, methyl ester(82340-98-5)

Safety Data

• Hazardous Substances Data: 82340-98-5(Hazardous Substances Data)

Upstream product

• 577-19-5 2-nitrophenyl bromide 
• 42058-59-3 3-hydroxy-benzeneacetic acid, methyl ester 
• 1493-27-2 ortho-nitrofluorobenzene 
• 621-37-4 m-hydroxyphenylacetic acid 

Downstream Products

• 840544-08-3 [3-(2-Amino-phenoxy)-phenyl]-acetic acid methyl ester 
• 721948-43-2 [3-(2-nitro-phenoxy)-phenyl]-acetic acid 

Relevant articles and documents

Evaluation and biological properties of reactive ligands for the mapping of the glycine site on the N-methyl-D-aspartate (NMDA) receptor

The glycine-binding site of the N-methyl-D-aspartate (NMDA) receptor, given its potential as pharmacological target, has been thoroughly studied by structure-activity relationships, which has made possible its description in terms of spatial limits and interactions of various types. A structural model, based on mutational analysis and sequence alignments, has been proposed. Yet, the amino acid residues responsible for the interactions with the ligand have not been unambiguously characterized. To evidence nucleophilic pocket-lining residues, we have designed and synthesized reactive glycine-site ligands derived from 3-substituted 4-hydroxy-quinolin- 2(1H)-ones by introducing various electrophilic groups at different positions of the molecule. These ligands were found to have high affinity at the glycine site and to be functional antagonists by inhibiting glycine/glutamate-induced currents in transfected oocytes. The correlation between their potency and their substitution pattern was strictly consistent with previously established structure-activity relationships. Most ligands displayed intrinsic reactivity toward cysteine, but none inactivated wild- type receptors. This is consistent with the model since it indicates the absence of exposed cysteine in the glycine-binding site. A strategy of cysteine incorporation by point mutations at selected polypeptide positions will create unambiguously localized targets for our reactive probes.

Nonsteroidal Antiinflammatory Agents. 1. 10,11-Dihydro-11-oxodibenzoxepinacetic Acids and Related Compounds

10,11-Dihydro-11-oxodibenzoxepinacetic acids and related compounds were synthesized as potential antiinflammatory agents.Among them, 2-(8-methyl-10,11-dihydro-11-oxodibenzoxepin-2-yl)propionic acid (16b) and its thiepin analogue (16c) showed excellent antipyretic activity together with potent antiinflammatory and analgesic properties in biological tests.Structure-activity relationships are discussed.