82363-24-4

Upstream product

• 104-94-9 4-methoxy-aniline 
• 93-03-8 (3,4-dimethoxyphenyl)methanol 
• 120-14-9 3,4-dimethoxy-benzaldehyde 

Downstream Products

• 98281-45-9 <4-Methoxy-anilin>-<3,4-dimethoxy-phenyl>-essigsaeure-nitril 
• 5415-56-5 2-phenyl-4-veratryliden-4H-oxazol-5-one 
• 1610556-39-2 C₂₁H₂₄ClNO₄ 
• 1610556-34-7 C₂₀H₂₅NO₃ 
• 1419351-64-6 benzyl ((E)-2-((2S,4R)-2-(3,4-dimethoxyphenyl)-6-methoxy-1,2,3,4-tetrahydroquinolin-4-yl)vinyl)carbamate 
• 1254709-08-4 (2S,3R)-tert-butyl 2-(2,6-dichlorobenzyloxy)-3-(3,4-dimethoxyphenyl)-3-(4-methoxyphenylamino) propanoate 
• 334708-41-7 [2R,3S,1'S,2'S]-(+)-(3,4-dimethoxyphenyl)-3-(4-methoxyphenylamino)-N,2-dimethyl-N-(2'-phenyl-2'-hydroxy-1'-methylethyl)propanamide 

Relevant academic research and scientific papers

Molecular design, synthesis, and biological evaluation of bisamide derivatives as cyclophilin A inhibitors for HCV treatment

Hepatitis C virus (HCV) is a major cause of end-stage liver diseases. Direct-acting antivirals (DAAs), including inhibitors of nonstructural proteins (NS3/4A protease, NS5A, and NS5B polymerase), represent key components of anti-HCV treatment. However, so

Novel N-Alkylbenzimidazole-Ruthenium (II) complexes: Synthesis and catalytic activity of N-alkylating reaction under solvent-free medium

In this article, direct N-alkylation reactions of amines with alcohols derivatives have been investigated. For this purpose, a new series ruthenium (II) complexes bearing N-coordinated benzimidazole complexes with have been synthesized and fully characterized by elemental analysis, FT-IR, 1H NMR and, 13C NMR spectroscopies. Additionally, the structures of the complexes 2b and 2c have been confirmed by X-ray crystallography. Although the N-alkylating reaction is usually performed in toluene, the catalytic study of complexes 2a-d has carried out no additional solvent and alcohol acted both as solvent and reactant of alkylating by using a little excess of alcohols. Surprisingly, conversion and selectivity of amine product for alkylation reaction have been seen high in medium solvent-free relative to in toluene.

Metal-Free Ring Opening Cyclization of Cyclopropane Carbaldehydes and N-Benzyl Anilines: An Eco-Friendly Access to Functionalized Benzo[b]azepine Derivatives

Herein, we report a p-toluenesulfonic acid (PTSA) initiated mild and user-friendly ring opening/domino ring opening cyclization reaction (depends on substituent present in N-benzyl aniline) of cyclopropane carbaldehyde and N-benzyl aniline towards the formation of substituted 4-amino butanal/2,3-dihydro-1H-benzo[b]azepine. The product dihydro-1H-benzo[b]azepine was also converted into the corresponding tetrahydro-1H-benzo[b]azepine. (Figure presented.).

NOVEL BIS-AMIDE DERIVATIVE AND USE THEREOF

The present invention relates to a novel bis-amide derivative compound or a pharmaceutically acceptable salt thereof; a method of preparation thereof; and a pharmaceutical composition for preventing or treating diseases caused by hepatitis C virus infecti

Solvent-free synthesis, spectral correlations and antimicrobial activities of some aryl imines

A series of aryl imines have been synthesized by Fly-ash: H 2SO4 catalyzed microwave assisted process under solvent-free conditions. The yields of the imines have been found to be more than 87%. The purity of all imines has been checked using their physical constants and spectral data as published earlier in literature. The UV λmaxCN(nm), infrared νCN(cm-1), NMR δ(ppm) of CH and CN spectral data have been correlated with Hammett substituent constants and F and R parameters using single and multi-linear regression analysis. From the results of statistical analysis, the effect of substituents on the above spectral data has been studied. The antimicrobial activities of All synthesised imines have been studied using Bauer-Kirby method.

Aqueous extract of the pericarp of Sapindus trifoliatus fruits: A novel 'green' catalyst for the aldimine synthesis

The catalytic efficiency in organic synthesis of the aqueous extract of the pericarp of Sapindus trifoliatus fruits was evaluated. The synthesis of a series of aldimines from aromatic aldehydes and amines was successfully catalyzed by the extract, whereas aromatic ketones and amines did not yield ketimines under comparable reaction conditions, indicating the chemoselective catalysis of the extract. The catalytic activity of the extract is due to saponins, which have a common structural skeleton containing a pentacyclic triterpenoid part substituted with different carbohydrate side chains. The mild conditions, high yields, and short reaction times not only make this protocol a valuable alternative to the conventional methods, but it also becomes significant under the roof of environmentally greener and safer processes.

Organocatalytic asymmetric Povarov reactions with 2- and 3-vinylindoles

The asymmetric Povarov reaction of N-arylimines with 2- and 3-vinylindoles has been developed using a chiral phosphoric acid ((S)-TRIP) as catalyst. The peculiar reactivity of vinylindoles allowed also the disclosure of a Povarov Friedel-Crafts sequence,

The Vilsmeier reagent: a useful and versatile reagent for the synthesis of 2-azetidinones

(Chloromethylene)dimethylammonium chloride (Vilsmeier reagent), prepared easily from N,N-dimethylformamide and oxalyl chloride or thionyl chloride, works as a versatile acid activator reagent for the direct [2+2] ketene-imine cycloaddition of substituted

Cu(OTf)2 or Et3N-catalyzed three-component condensation of aldehydes, amines and cyanides: a high yielding synthesis of α-aminonitriles

Copper(II) triflate or Et3N have been found to catalyze, under ambient conditions, the addition of a cyanide anion, such as trimethylsilyl cyanide or acetone cyanohydrin, onto in situ generated imines, furnishing α-aminonitriles in excellent yi

(+)-(S,S)-pseudoephedrine as a chiral auxiliary in asymmetric Mannich reactions: Scope and limitations

The Mannich reaction of variously substituted (+)-(S,S)-pseudoephedrine amides with either enolizable and nonenolizable imines smoothly afforded a series of β-substituted α-alkyl-β-amino amides with full stereochemical control. These Mannich adducts have