82376-73-6Relevant academic research and scientific papers
Metal-Free Ring Opening Cyclization of Cyclopropane Carbaldehydes and N-Benzyl Anilines: An Eco-Friendly Access to Functionalized Benzo[b]azepine Derivatives
Dey, Raghunath,Banerjee, Prabal
, p. 2849 - 2854 (2019/04/26)
Herein, we report a p-toluenesulfonic acid (PTSA) initiated mild and user-friendly ring opening/domino ring opening cyclization reaction (depends on substituent present in N-benzyl aniline) of cyclopropane carbaldehyde and N-benzyl aniline towards the formation of substituted 4-amino butanal/2,3-dihydro-1H-benzo[b]azepine. The product dihydro-1H-benzo[b]azepine was also converted into the corresponding tetrahydro-1H-benzo[b]azepine. (Figure presented.).
Method for preparing secondary amine compound through imine hydrogenation reduction
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Paragraph 0055-0058, (2019/12/02)
The invention belongs to the technical field of medical and natural compound chemical intermediates and related chemistry, and provides a method for preparing secondary amine compounds through imine hydrogenation reduction. According to the method, the im
Novel N-Alkylbenzimidazole-Ruthenium (II) complexes: Synthesis and catalytic activity of N-alkylating reaction under solvent-free medium
?ahin, Neslihan,?zdemir, Nam?k,Gürbüz, Nevin,?zdemir, ?smail
, (2019/01/04)
In this article, direct N-alkylation reactions of amines with alcohols derivatives have been investigated. For this purpose, a new series ruthenium (II) complexes bearing N-coordinated benzimidazole complexes with have been synthesized and fully characterized by elemental analysis, FT-IR, 1H NMR and, 13C NMR spectroscopies. Additionally, the structures of the complexes 2b and 2c have been confirmed by X-ray crystallography. Although the N-alkylating reaction is usually performed in toluene, the catalytic study of complexes 2a-d has carried out no additional solvent and alcohol acted both as solvent and reactant of alkylating by using a little excess of alcohols. Surprisingly, conversion and selectivity of amine product for alkylation reaction have been seen high in medium solvent-free relative to in toluene.
Application of a catalyst-free Domino Mannich/Friedel-Crafts alkylation reaction for the synthesis of novel tetrahydroquinolines of potential antitumor activity
Castillo, Juan-Carlos,Jiménez, Elizabeth,Portilla, Jaime,Insuasty, Braulio,Quiroga, Jairo,Moreno-Fuquen, Rodolfo,Kennedy, Alan R.,Abonia, Rodrigo
, p. 932 - 947 (2018/02/09)
A useful and efficient method to construct diversely substituted 1,2,3,4-tetrahydroquinolines in good to excellent yields has been developed through a catalyst-free Domino Mannich and intramolecular Friedel-Crafts alkylation reactions of N-arylamines with
Parallel solution synthesis of lavendustin analogs as antileishmanial agents
Ghiano, Diego G.,Carvalho, Paulo B.,Tekwani, Babu L.,Avery, Mitchell A.,Labadie, Guillermo
experimental part, p. 297 - 311 (2011/06/19)
A concise parallel synthesis of 12 lavendustin analogs is described. Starting with differently substituted benzaldehydes, a two-step sequence involving reductive amination and N-benzylation accelerated by microwaves was performed to provide the compounds
