334708-41-7

Upstream product

• 130632-09-6 (E)-1-(3,4-dimethoxyphenyl)-N-(4-methoxyphenyl)methanimine 
• 159213-03-3 N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N-methylpropionamide 
• 82363-24-4 (3,4-dimethoxybenzylidene)-(4-methoxyphenyl)amine 

Downstream Products

• 334708-46-2 [2R,3S]-(-)-methyl 3-(3,4-dimethoxyphenyl)-3-(4-methoxyphenylamino)-2-methylpropanoate 

Relevant academic research and scientific papers

Asymmetric synthesis of beta-substituted alpha-methyl-beta-amino esters by Mannich reaction of (S,S)-(+)-pseudoephedrine acetamide derived enolate with imines.

[reaction: see text]. The reaction of an (S,S)-(+)-pseudoephedrine acetamide based enolate with several imines afforded smoothly and with full stereochemical control a series of beta-substituted alpha-methyl-beta-aminoamides that upon hydrolysis/esterific

(+)-(S,S)-pseudoephedrine as a chiral auxiliary in asymmetric Mannich reactions: Scope and limitations

The Mannich reaction of variously substituted (+)-(S,S)-pseudoephedrine amides with either enolizable and nonenolizable imines smoothly afforded a series of β-substituted α-alkyl-β-amino amides with full stereochemical control. These Mannich adducts have