82372-89-2Relevant academic research and scientific papers
Enantioselective hydrogen transfer reactions from chiral binaphthyl variants of tin hydrides to prochiral radicals
Blumenstein, Michael,Lemmler, Matthias,Hayen, Ahlke,Metzger, Juergen O.
, p. 3069 - 3077 (2007/10/03)
Enantioselective, reagent-controlled radical reductions of prochiral alkyl radicals, mediated by binaphthyl variants of tin hydrides can be carried out in a highly selective fashion: a maximum selectivity of 68% e.e. was reached. Temperature, solvent, Lewis acid and substituent effects are selectivity-controlling elements. The reactions can be conducted catalytically with 1 mol% of chiral information and excess NaCNBH3.
Catalytic Asymmetric C-H Activation of Alkanes and Tetrahydrofuran
Davies, Huw M. L.,Hansen, Tore,Churchill, Melvyn Rowen
, p. 3063 - 3070 (2007/10/03)
Rhodium carbenoids derived from methyl aryldiazoacetates are capable of effective catalytic asymmetric C-H activation of a range of alkanes and tetrahydrofuran by a C-H insertion mechanism. Dirhodium tetrakis(S-(N-dodecylbenzenesulfonyl)prolinate) (Rh2(S-DOSP)4) catalyzed decomposition of methyl aryldiazoacetates in the presence of alkanes results in intermolecular C-H insertions with good control of regioselectivity, diastereoselectivity, and enantioselectivity. The carbenoids derived from methyl aryldiazoacetates are considerably more chemoselective than carbenoids derived from diazoacetates. They strongly favor C-H insertions into secondary and tertiary sites. Formation of side products due to carbene dimerization is not a major problem with rhodium carbenoids derived from aryldiazoacetates.
Configuration Determination of (R)-(-)-1,1,2-Triphenyl-3,3-dimethylbutane and the Stereochemistry of the Reaction of Benzhydryllithium with (R)-(+)-α-Phenylneopentyl Chloride
Bright, Danielle Angrand,Mathisen, Donald E.,Zieger, Herman E.
, p. 3521 - 3524 (2007/10/02)
A three-step synthesis of optically pure (R)-(-)-1,1,2-triphenyl-3,3-dimethylbutane from (R)-(-)-α-tert-butylphenylacetic acid has been accomplished.The synthesis of α-phenylneopentyl chloroformate from optically pure (R)-(+)-1-phenyl-2,2-dimethyl-1-propa
