82378-47-0

Basic information

• Product Name: (2R)-2-(1-Methylethyl)oxirane
• Synonyms: (2R)-2-(1-Methylethyl)oxirane;(R)-Isopropyloxirane
• CAS NO: 82378-47-0
• Molecular Formula: C₅H₁₀O
• Molecular Weight: 86.13
• Mol File: 82378-47-0.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 75 ºC
• Flash Point: -8 ºC
• Appearance: /
• Density: 0.893
• Vapor Pressure: 116mmHg at 25°C
• Refractive Index: 1.425
• CAS DataBase Reference: (2R)-2-(1-Methylethyl)oxirane(CAS DataBase Reference)
• NIST Chemistry Reference: (2R)-2-(1-Methylethyl)oxirane(82378-47-0)
• EPA Substance Registry System: (2R)-2-(1-Methylethyl)oxirane(82378-47-0)

Safety Data

• Hazardous Substances Data: 82378-47-0(Hazardous Substances Data)

Usage

General Description

The chemical compound "(2R)-2-(1-Methylethyl)oxirane" is also known as isopropyl oxirane. It is a colorless liquid with a faint, sweet odor. (2R)-2-(1-Methylethyl)oxirane is commonly used as a solvent, intermediate, and in the production of other chemicals such as pharmaceuticals, agrochemicals, and polymers. It is also used in the synthesis of epoxy resins and as an intermediate in the production of specialty chemicals. Additionally, it is found in trace amounts in some food products such as baked goods, fruits, and alcoholic beverages. However, it is important to handle this compound with care as it can be harmful if inhaled or ingested, and may also cause skin and eye irritation.

InChI:InChI=1/C5H10O/c1-4(2)5-3-6-5/h4-5H,3H2,1-2H3/t5-/m0/s1

Upstream product

• 1438-14-8 2-isopropyloxirane 
• 72-18-4 L-valine 
• 640-68-6 D-Val-OH 
• 921-08-4 (S)-2-chloro-3-methylbutyric acid 
• 82378-45-8 (S)-2-chloro-3-methylbutyl alcohol 

Downstream Products

• 916912-66-8 (S)-7-Benzyloxy-2-methyl-hept-5-yn-3-ol 
• 1574555-40-0 C₂₅H₃₇Cl₂NO₂Si 
• 1430056-05-5 (3S)-2-methyl-9-en-3-yl-2,3,4-tri-O-benzoyl-6-O-(3-benzyloxycarbonylpropanoyl)-β-D-glucopyranoside 
• 1430056-31-7 (S)-2-methyldec-9-en-3-yl 4-nitrobenzoate 

Relevant articles and documents

CRYSTALLINE FORMS OF A CD73 INHIBITOR

The present invention relates to crystalline forms of 5-[5-[2-isopropylcyclopropyl] -6-methyl-pyridazin-3-yl]-1H-pyrimidine-2,4-dione, and pharmaceutical compositions comprising them, which inhibit the activity of CD73 and are useful for treating cancer.

Total Synthesis and Biological Evaluation of the Glycosylated Macrocyclic Antibiotic Mangrolide A

The macrocyclic antibiotic mangrolide A has been described to exhibit potent activity against a number of clinically important Gram-negative pathogens. Reported is the first enantioselective total synthesis of mangrolide A and derivatives. Salient features of this synthesis include a highly convergent macrocycle preparation, stereoselective synthesis of the disaccharide moiety, and two β-selective glycosylations. The synthesis of mangrolide A and its analogues enabled the re-examination of its activity against bacterial pathogens, and only minimal activity was observed.

SMALL MOLECULE COMPOUNDS SELECTIVE AGAINST GRAM-NEGATIVE BACTERIAL INFECTIONS

The described invention provides fully synthetic, biologically active mangrolide A. It describes schemes to chemically synthesize mangrolide A, intermediates and analogs of mangrolide A, and their antibacterial activity.