1438-14-8

Usage

Uses

1,2-Epoxy-3-methylbutane is used as a pharmaceutical intermediate.

InChI:InChI=1/C5H10O/c1-4(2)5-3-6-5/h4-5H,3H2,1-2H3/t5-/m1/s1

Upstream product

• 563-45-1 3-Methyl-1-butene 
• 123-51-3 i-Amyl alcohol 

Downstream Products

• 17687-58-0 1-amino-3-methylbutan-2-ol 
• 65534-62-5 (3R^*,5S^*)-2,6-dimethyl-3,5-heptanediol 
• 36471-61-1 racem. 2,6-dimethyl-heptane-3,5-diol 
• 138056-20-9 1-Diphenylphosphanyl-3-methyl-butan-2-ol 
• 82378-47-0 (R)-2-isopropyloxirane 
• 55123-01-8 (S)-(+)-1,2-epoxy-3-methylbutane 
• 763-32-6 2-methyl-1-buten-4-ol 
• 115-18-4 2-methyl-3-buten-2-ol 
• 598-75-4 3-methyl-2-butanol 
• 123-51-3 i-Amyl alcohol 
• 556-82-1 3-methyl-2-buten-1-ol 
• 50468-22-9 3-methylbutane-1,2-diol 
• 563-80-4 3-methyl-butan-2-one 
• 35158-25-9 2-isopropyl-5-methyl-hex-2-enal 

Relevant academic research and scientific papers

Cyclopropenone catalyzed substitution of alcohols with mesylate ion

The cyclopropenone catalyzed nucleophilic substitution of alcohols by methanesulfonate ion with inversion of configuration is described. This work provides an alternative to the Mitsunobu reaction that avoids the use of azodicarboxylates and generation of hydrazine and phosphine oxide byproducts. This transformation is shown to be compatible with a range of functionality. A cyclopropenone scavenge strategy is demonstrated to aid purification.

5- substituted tetralones as inhibitors of ras farnesyl trransferase

The present invention provides novel 5-substituted tetralones of Formulas (I), (II), (III) and (IV) and pharmaceutically acceptable salts, esters, amides, and prodrugs thereof, which are useful for treating and preventing uncontrolled or abnormal proliferation of tissues, such as cancer, atherosclerosis, restenosis, and psoriasis. Specifically, the present invention relates to compounds that inhibit the farnesyl transferase enzyme.

Synthesis of Cyclic Organic Carbonates from C3-C16 Epoxides

Cyclic organic carbonates were prepared from epoxides (derivatives of C3-C16 olefins, C4 and C8 dienes, styrene; epichlorohydrin) in the presence of a catalytic system consisting of CoCl2 · 6H2O and dimethylformamide.

EPOXIDATION AND/OR HYDROXYLATION OF 3-METHYLBUT-1-ENE BY ORGANIC HYDROPEROXIDES AND HYDROGEN PEROXIDE

An examination has been made of the hydroperoxide and peroxide epoxidation of 3-methylbut-1-ene.The indices of hydroperoxide epoxidation are given.A mathematical model of the production of tert-amyl hydroperoxide by the liquid-phase oxidation of isopentane has been developed.The optimum conditions have been selected for the epoxidation of 3-methylbut-1-ene to the corresponding oxide and diol under interphase catalysis conditions.

DIRECT LIQUID-PHASE OXIDATION OF 3-METHYLBUT-1-ENE BY ATMOSPHERIC OXYGEN

An examination has been made of different variants of the direct oxidation of 3-methylbut-1-ene by atmospheric oxygen in the liquid phase.The most promising of the variants examined for the oxidation of this α-isoamylene is direct oxidation in the presence of a bimetallic catalytic system.Target products were isolated from the oxidate - 3-metyhylbut-1-ene oxide and dimethylvinylcarbinol of sufficient purity.

Dissociation of Positively Charged Aliphatic Epoxides. II. +. Epoxides and α,β Unsaturated Ethers

The unimolecular dissociations of C5 epoxides ions mono- or disubstituted at C1 give exclusive loss of CH3 and exclusive formation of methoxyvinyl carbenium ion, both in the source and in the 2nd field-free region.In the case of the 1,2-disubstituted ion in the 2nd field-free region the loss of ethene is the only pathway, while a competition occurs for the trisubstituted ion leading to +. and +. ions, the structure of which are demonstrated.The first step of the different mechanisms is the cleavage of the heterocyclic C-C bond.

Synthesis and Insecticidal Activity of Oxazaphospholidines, Oxathiaphospholanes, and Thiazaphospholidines

Fifty-five new five-membered cyclic organophosphorus compounds including oazaphospholidines, thiazaphospholidines, and oxathiaphospholanes were synthesized, which have substituents at 4- or/and 5-positions besides at the 2-position.The thiazaphospholidines showed the highest insecticidal activity followed by oxathiaphospholanes and oxazaphospholidines.The position preference of substituents in insecticidal activity was most obvious in the oxazaphospholidines.It was preferable for insecticidal activity to have the substituent near the more basic atom: the 4-position for thiazaphospholidine and oxazaphospholidine, the 5-position for oxathiaphospholane, with the exception of 4- or 5-phenyl oxazaphospholidine.