82419-26-9

Basic information

• Product Name: 2,3-DIFLUORO-6-NITROPHENOL
• Synonyms: 2,3-DIFLUORO-6-NITROPHENOL;2-HYDROXY-3,4-DIFLUORO NITROBENZENE;6-NITRO-2,3-DIFLUOROPHENOL;2,3-Didluoro-6-nitrophenol;2,3-Difluoro-6-Nitrophenol98%;2,3-Difluoro-6-nitrophenol, 97+%;Difluoro-6-nitrophenol;2,3-Difluoro-6-nitrophenol 97%
• CAS NO: 82419-26-9
• Molecular Formula: C₆H₃F₂NO₃
• Molecular Weight: 175.09
• EINECS: 212-535-9
• Product Categories: Aromatic Phenols;Benzene series;Phenol&Thiophenol&Mercaptan;Organic Building Blocks;Oxygen Compounds;Phenols
• Mol File: 82419-26-9.mol
• Article Data: 6

Chemical Properties

• Melting Point: 60-62 °C(lit.)
• Boiling Point: 215.9 °C at 760 mmHg
• Flash Point: 84.4 °C
• Appearance: /
• Density: 1.5200 (estimate)
• Vapor Pressure: 0.0984mmHg at 25°C
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 4.77±0.37(Predicted)
• BRN: 4410368
• CAS DataBase Reference: 2,3-DIFLUORO-6-NITROPHENOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-DIFLUORO-6-NITROPHENOL(82419-26-9)
• EPA Substance Registry System: 2,3-DIFLUORO-6-NITROPHENOL(82419-26-9)

Safety Data

• Hazard Codes: Xn,T,Xi
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36-36/37/39
• WGK Germany: 3
• HazardClass: IRRITANT, IRRITANT-HARMFUL
• Hazardous Substances Data: 82419-26-9(Hazardous Substances Data)

Usage

Chemical Properties

yellow crystals

Uses

2,3-Difluoro-6-nitrophenol was used in the synthesis of 2-methyl-6,7-difluoro-8-oxyquinoline.

InChI:InChI=1/C6H3F2NO3/c7-3-1-2-4(9(11)12)6(10)5(3)8/h1-2,10H/p-1

Upstream product

• 2646-83-5 3,3,4,4-tetrafluorocyclohexene 
• 771-69-7 2,3,4-trifluoronitrobenzene 
• 124-41-4 sodium methylate 

Downstream Products

• 115551-33-2 2-hydroxy 3,4-difluoro aniline 
• 82419-27-0 2-(2-bromoethoxy)-3,4-difluoronitrobenzene 
• 457099-10-4 1-[3,4-Difluoro-2-(pyridin-3-ylmethoxy)-phenyl]-3-(5-methyl-pyrazin-2-yl)-urea 
• 441713-58-2 2-benzyloxy-3,4-difluoro-1-nitrobenzene 
• 186750-51-6 (S)-1-(6-amino-2,3-difluorophenoxy)propan-2-ol 
• 124409-98-9 (R)-1-(6-amino-2,3-difluorophenoxy)propan-2-ol 
• 145757-92-2 (R)-1-(2,3-difluoro-6-nitrophenoxy)propan-2-yl acetate 
• 124506-30-5 2,3-Difluoro-6-nitro-{[(S)-2-hydroxypropyl]oxy}benzene 
• 124409-94-5 2,3-difluoro-6-nitro{[(R)-2-hydroxypropyl]oxy}benzene 

Relevant articles and documents

Synthesis of fluorinated halonitrobenzenes and halonitrophenols using tetrafluoroethylene and buta-1,3-dienes as starting building blocks

The gas-phase copyrolysis of tetrafluoroethylene with buta-1,3-diene in a flow reactor at 495–505 °C produces 3,3,4,4-tetrafluorocyclohex-1-ene, which selectively converted to 1,2-difluorobenzene or 1-chloro-2,3-difluorobenzene. The latter can be converted to 2-chloro-3,4-difluoronitrobenzene, 2,3,4-trifluoronitrobenzene, 2,3-difluoro-6-nitrophenol, or 2-chloro-3-fluoro-4-nitrophenol via nitration, fluorodechlorination, and hydrolysis reactions.

Process for producing 2,3-difluoro-6-nitrophenol

According to a process for producing isomer-free 2,3-difluoro-6-nitrophenol, 2,3,4-trifluoronitrobenzene is reacted with an aqueous solution of alkali metal or alkaline earth metal hydroxide in the absence of organic solvent, at temperatures between about

Synthesis and antibacterial activities of substituted 7-oxo-2,3-dihydro-7h-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acids

As part of a search for new synthetic antibacterial agents to combat systemic infection, various analogues of 7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acids were synthesized. Among the compounds newly synthesized, 9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido[ 1,2,3-de][1,4]benzoxazine-6-carboxylic acid (DL-8280) showed potent antibacterial activity against Gram-positive and -negative pathogens, including Psedomonas aeruginosa, and its metabolic disposition was shown in separate experimentals to be favorable.