82425-35-2

Usage

Uses

Used in Pharmaceutical Industry:
20-O-Acetylingenol-3-angelate is used as an anti-cancer agent for its potential to inhibit the growth and proliferation of cancer cells. It may target specific signaling pathways or cellular processes that contribute to tumor development and progression, offering a novel therapeutic approach for cancer treatment.
Used in Veterinary Medicine:
In the veterinary medicine industry, 20-O-Acetylingenol-3-angelate is used as a molluscicidal agent. It is present in extracts from Euphorbia conspicua N. E. Br. and has been found to be effective in controlling and eliminating snail and slug populations, which can be beneficial for agricultural and environmental purposes.
Used in Cytotoxicity Research:
20-O-Acetylingenol-3-angelate is also used as a cytostatic agent in research settings. Its ability to inhibit cell growth and division makes it a valuable tool for studying the mechanisms of cell cycle regulation and identifying potential targets for therapeutic intervention in various diseases, including cancer.

Upstream product

• 108-24-7 acetic anhydride 
• 75567-37-2 ingenol mebutate 
• 108-05-4 vinyl acetate 
• 87980-68-5 3-O-angeloyl-5,20-O-isopropylideneingenol 

Relevant academic research and scientific papers

Regioselective acylation of 3-O-angeloylingenol by Candida antarctica Lipase B

Acylation of 3-O-angeloylingenol (1) with vinyl acetate, vinyl decanoate and vinyl cinnamate, catalyzed by Candida antarctica Lipase B, was investigated. In each case, compound 1 was quantitatively and regioselectively acylated to afford a single product,

Syntheses, biological evaluation and SAR of ingenol mebutate analogues for treatment of actinic keratosis and non-melanoma skin cancer

Ingenol mebutate is the active ingredient in Picato a new drug for the treatment of actinic keratosis. A number of derivatives related to ingenol mebutate were prepared by chemical synthesis from ingenol with the purpose of investigating the SAR and potency in assays relating to pro-inflammatory effects (induction of PMN oxidative burst and keratinocyte cytokine release), the potential of cell death induction, as well as the chemical stability. By modifications of the ingenol scaffold several prerequisites for activity were identified. The chemical stability of the compounds could be linked to an acyl migration mechanism. We were able to find analogues of ingenol mebutate with comparable in vitro properties. Some key features for potent and more stable ingenol derivatives have been identified.