82471-86-1

Upstream product

• 24425-40-9 indan-5-amine 
• 124-63-0 methanesulfonyl chloride 

Downstream Products

• 82471-91-8 N-[6-(4-Fluoro-benzoyl)-indan-5-yl]-methanesulfonamide 
• 82471-88-3 N-[6-(4-Chloro-benzoyl)-indan-5-yl]-methanesulfonamide 
• 82471-90-7 N-[6-(3-Fluoro-benzoyl)-indan-5-yl]-methanesulfonamide 
• 82471-89-4 N-[6-(2-Fluoro-benzoyl)-indan-5-yl]-methanesulfonamide 
• 82471-94-1 N-<6-(α-Ethoxybenzyl)-5-indanyl>-methansulfonamid 
• 82471-93-0 N-<6-(α-Hydroxybenzyl)-5-indanyl>-methansulfonamid 
• 82471-95-2 N-<6-(1-Hydroxy-1-phenylethyl)-5-indanyl>-methansulfonamid 
• 82471-92-9 N-(6-Benzyl-5-indanyl)-methansulfonamid 
• 82471-96-3 N-<6-(1-Phenylvinyl)-5-indanyl>-methansulfonamid 
• 82471-87-2 N-(6-Benzoyl-5-indanyl)-methansulfonamid 

Relevant academic research and scientific papers

Amide compound for prevention and treatment of mental disorders

The present invention relates to an amide compound for prevention and treatment of mental disorders, which is shown as a formula (I), a pharmaceutically acceptable salt thereof, a prodrug thereof, a solvate thereof, a deuterated substance or a stereoisomer thereof. Wherein R1, R2, R3, R4, R5, Ar1, Ar2, p and q are as defined in the specification. The invention also relates to a preparation methodof the amide compound, a pharmaceutical composition and a pharmaceutical preparation containing the amide compound, and an application of the compound in preparation of a drug for prevention or treatment of mental disorders such as depression, depression and anxiety, and schizophrenia.

1,3,4-OXADIAZOLE SULFONAMIDE DERIVATIVE COMPOUNDS AS HISTONE DEACETYLASE 6 INHIBITOR, AND THE PHARMACEUTICAL COMPOSITION COMPRISING THE SAME

The present invention relates to novel compounds represented by the formula I having histone deacetylase 6 (HDAC6) inhibitory activity, stereoisomers thereof or pharmaceutically acceptable salts thereof, the use thereof for the preparation of therapeutic medicaments, pharmaceutical compositions containing the same, a method for treating diseases using the composition, and methods for preparing the novel compounds. (I) The novel compounds, stereoisomers thereof or pharmaceutically acceptable salts thereof according to the present invention have histone deacetylase (HDAC) inhibitory activity and are effective for the prevention or treatment of HDAC6-mediated diseases.

Non-steroidal antiinflammatory agents. Part VII. Methane sulfonanilides

Synthesis and antiinflammatory activity (rat) of indane derivatives related to the potent antiinflammatory N-(6-phenoxy-5-indanyl) methane sulfonamide are described. The following structure activity relationships can be recognized. Replacement of the O atom of the phenoxy residue by a direct bond, a (substituted) methylene or a carbonyl group only in the latter case led to active compounds. In general, modification of the methane sulfonamide moiety resulted in loss of activity, however, the chloro- and fluoro-methanesulfonamides, as well as the N-acetyl methanesulfonamide proved to be active. When the phenyl ring was replaced by cyclohexyl, naphthyl or heterocyclic ring systems, activities were found only in the pyridyloxy derivatives