82471-96-3Relevant articles and documents
Non-steroidal antiinflammatory agents. Part VII. Methane sulfonanilides
Schroeder,Lehmann,Rufer,Bottcher
, p. 165 - 172 (2007/10/02)
Synthesis and antiinflammatory activity (rat) of indane derivatives related to the potent antiinflammatory N-(6-phenoxy-5-indanyl) methane sulfonamide are described. The following structure activity relationships can be recognized. Replacement of the O atom of the phenoxy residue by a direct bond, a (substituted) methylene or a carbonyl group only in the latter case led to active compounds. In general, modification of the methane sulfonamide moiety resulted in loss of activity, however, the chloro- and fluoro-methanesulfonamides, as well as the N-acetyl methanesulfonamide proved to be active. When the phenyl ring was replaced by cyclohexyl, naphthyl or heterocyclic ring systems, activities were found only in the pyridyloxy derivatives
