824935-60-6Relevant academic research and scientific papers
Design, synthesis and biological evaluation of 4-anilinoquinoline derivatives as novel potent tubulin depolymerization agents
Zhou, Yuanyuan,Yan, Wei,Cao, Dong,Shao, Mingfeng,Li, Dan,Wang, Fang,Yang, Zhuang,Chen, Yong,He, Linhong,Wang, Taijin,Shen, Mingsheng,Chen, Lijuan
supporting information, p. 1114 - 1125 (2017/08/02)
A series of novel 4-anilinoquinoline derivatives were synthesized and evaluated for their antiproliferative activities. Among them, 14h exhibited the most potent cytotoxic activity with IC50 values ranging from 1.5 to 3.9 nM against all tested cancer cell lines, and showed promising efficacy in multidrug resistant cancer cells. Flow cytometry assay, immune-fluorescence staining, microtubule dynamics assays and competition assays with EBI identified that 14h was a novel tubulin depolymerization agent by binding to the colchicine site. Importantly, in vivo efficacy evaluation of HCT116 xenograft model, 14h showed efficient antitumor activity without significant loss in body weight. All the results indicated that 14h could be a promising candidate for the treatment of cancer.
Synthesis and anticancer evaluation of certain indolo[2,3-b]quinoline derivatives
Chen, Yeh-Long,Hung, Hsien-Ming,Lu, Chih-Ming,Li, Kuang-Chieh,Tzeng, Cherng-Chyi
, p. 6539 - 6546 (2007/10/03)
The present report describes the synthesis and anticancer evaluation of certain 11-substituted 6H-indolo[2,3-b]quinolines and their methylated derivatives. These 6H-indolo[2,3-b]quinoline derivatives 11-13 were prepared from the commercially available 1,4
