824938-85-4

Basic information

• Product Name: Carbamic acid, [(1S,2S)-2-(1-piperidinyl)cyclohexyl]-, phenylmethyl ester
• CAS NO: 824938-85-4
• Molecular Formula: C19H28N2O2
• Molecular Weight: 316.444
• Mol File: 824938-85-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Carbamic acid, [(1S,2S)-2-(1-piperidinyl)cyclohexyl]-, phenylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [(1S,2S)-2-(1-piperidinyl)cyclohexyl]-, phenylmethyl ester(824938-85-4)
• EPA Substance Registry System: Carbamic acid, [(1S,2S)-2-(1-piperidinyl)cyclohexyl]-, phenylmethyl ester(824938-85-4)

Safety Data

• Hazardous Substances Data: 824938-85-4(Hazardous Substances Data)

Upstream product

• 18468-90-1 (+/-)-trans-2-(piperidin-1-yl)cyclohexanamine 
• 141-78-6 ethyl acetate 
• 501-53-1 benzyl chloroformate 
• 110-89-4 piperidine 
• 286-20-4 cyclohexane-1,2-epoxide 
• 7581-94-4 trans-2-(pipoeridin-1-yl)cyclohexanol 

Downstream Products

• 824938-80-9 (1S, 2S)-trans-2-(1-piperidinyl)cyclohexylamine 

Relevant articles and documents

Chemoenzymatic preparation of optically active trans-cyclohexane-1,2- diamine derivatives: An efficient synthesis of the analgesic U-(-)-50,488

Stereoespecific syntheses of (±)-trans-N,N-cyclohexane-1,2-diamines ((±)-4a-g) were carried out from the corresponding (±)-trans-N,N- dialkylaminocyclohexanols by successive treatment with mesyl chloride and aqueous ammonia. The stereochemical outcome indicates the formation of a meso-aziridinium ion intermediate, Kinetic resolutions of diamines (±)-4 were efficiently accomplished in aminolysis reactions catalyzed by lipase B from Candida antarctica with ethyl acetate as the solvent and acyl donor. Acetamides and the remaining diamines, isolated as the benzyloxycarbonyl derivatives, were obtained with very high ee values (92-99%), One of the carbamates was used as a precursor of the analgesic U-(-)-50,488.