824955-28-4Relevant academic research and scientific papers
Solid-phase synthesis of lipidated peptides
Kragol, Goran,Lumbierres, Maria,Palomo, Jose M.,Waldmann, Herbert
, p. 5839 - 5842 (2004)
Blockers, anchors, and reporters: A solid-phase method for the synthesis of lipidated peptides (see scheme) relies on the base-labile Fmoc group to block the N-terminus, an oxidation-labile hydrazide linker for anchoring to the solid support, and lipidate
Solid-phase synthesis of lipidated peptides
Lumbierres, Maria,Palomo, Jose M.,Kragol, Goran,Roehrs, Sonja,Mueller, Oliver,Waldmann, Herbert
, p. 7405 - 7415 (2008/03/28)
A new flexible and efficient methodology for the solid-phase synthesis of lipidated peptides has been developed. The approach is based on the use of previously synthesized building blocks and overcomes the limitations of previously reported methods, since long doubly lipidated peptides can be synthesized by using this route. Furthermore, it was thus possible to prepare a large number of N- and H-Ras peptides bearing a wide range of reporter and/or linking groups - efficient tools for the investigation of biological processes. In terms of efficiency and flexibility this solid-phase method is superior to the solution-phase synthesis. It gives pure peptides in multi-milligram amounts within a much shorter time and with superior overall yield.
