82543-85-9

Usage

Uses

Used in Pharmaceutical Industry:
Deoxyhypusine is used as a pharmaceutical intermediate for the synthesis of hypusine-containing compounds. These compounds have potential applications in the development of drugs targeting various diseases, including cancer and viral infections. The unique structure of deoxyhypusine allows for the design of specific inhibitors or activators of enzymes and proteins involved in these diseases.
Used in Research Applications:
Deoxyhypusine is used as a research tool for studying the role of hypusine in cellular processes and the mechanisms of its formation. It can be employed in biochemical assays, enzyme activity studies, and the development of novel inhibitors or activators targeting the enzymes involved in hypusine synthesis. This research can provide valuable insights into the regulation of protein function and the potential therapeutic applications of hypusine-containing compounds.
Used in Diagnostic Applications:
Deoxyhypusine can be used as a diagnostic marker for certain diseases or conditions, as alterations in the levels of deoxyhypusine or its metabolites may indicate the presence of specific disorders. The measurement of deoxyhypusine in biological samples can be achieved using various analytical techniques, such as mass spectrometry or enzyme-linked immunosorbent assays (ELISA), providing a means to monitor disease progression or the effectiveness of treatments.

InChI:InChI=1/C10H23N3O2/c11-6-2-4-8-13-7-3-1-5-9(12)10(14)15/h9,13H,1-8,11-12H2,(H,14,15)/t9-/m0/s1

Upstream product

• 13734-28-6 Boc-Lys-OH 
• 56-87-1 L-lysine 
• 214051-92-0 2(S)-Amino-11-[(benzyloxycarbonyl)amino]7-(carbobenzyloxy)-7-azaundecanoic Acid 
• 189280-15-7 tert-butyl(2S,9R)-11-[(benzyloxycarbonyl)amino]-2-[(tert-butoxycarbonyl)amino]-9-hydroxy-7-(benzyloxycarbonyl)-7-azaundecanoate 
• 214051-93-1 11-[(Benzyloxycarbonyl)amino]-7-(carbobenzyloxy)-2(S)-[(9-fluorenylmethoxycarbonyl)amino]-7-azaundecanoic Acid 

Relevant academic research and scientific papers

A kind of amino acid- the amine decorates composition and its preparation method and application

The invention belongs to the field of medicinal chemistry and in particular relates to amino acid-amine conjugate and a preparation method and application thereof. A general formula of the amino acid-amine conjugate is shown in the specification. According to the amino acid-amine conjugate, amino acid and amine are combined together, the water solubility, biological properties and drug targeting of amine compounds can be improved, and anti-cancer targeting can be realized.

Synthesis of reagents for the construction of hypusine and deoxyhypusine peptides and their application as peptidic antigens

Two new synthetic methods which allow access to (2S)-deoxyhypusine, natural (2S,9R)-hypusine, (2S,9S)-hypusine, and deoxyhypusine- and hypusine- containing peptides are described. The methods involve both the construction of a deoxyhypusine reagent in which the α-nitrogen protecting group is orthogonal to the N-7 and N-12 protecting groups and an alternate synthesis of our previous hypusine reagent, a synthesis which provides for better stereochemical control at C-9. Synthetic hypusine and deoxyhypusine can be generated from these reagents. The hypusine-containing hexapeptide (Cys-Thr- Gly-Hpu-His-Gly) is conjugated to ovalbumin (OVA), keyhole limpet hemocyanin (KLH), and a bis-maleimide; KLH conjugates are also made with the deoxyhypusine- and lysine-containing hexapeptides. Monoclonal antibodies are generated to the hypusine-containing hexapeptide-OVA conjugate in mice. These are isolated and screened against the hypusine-containing hexapeptide-KLH and hypusine-containing hexapeptide-bis-maleimide conjugates, as well as against the deoxyhypusine-containing and lysine-containing hexapeptide-KLH conjugates. These antibodies may be useful in localizing intracellular hypusine-containing peptides as well as peptides containing hypusine analogues.

Determination of covalently bound hypusine and deoxyhypusine to protein using submilligram of protein samples by HPLC

A sensitive and reliable method for the determination of hypusine and deoxyhypusine in elF-5A protein, an initiation factor of protein synthesis, was developed. An advantage of this method is the use of N(ε)-(5- aminopentyl)lysine, an analogue of deoxyhyp