825633-94-1

Usage

Uses

Used in Organic Chemistry Research:
5-Iodo-2,3-dihydropyridazin-3-one is used as a research compound for exploring its chemical properties and potential applications in organic chemistry. Its unique structure with a halogen atom and a pyridazine ring may offer insights into the synthesis and reactivity of related compounds.
Used in Pharmaceutical Development:
Although not well-documented, 5-Iodo-2,3-dihydropyridazin-3-one may be used as a starting material or intermediate in the synthesis of pharmaceutical compounds. Its potential biological activity could be investigated for the development of new drugs, particularly in the context of its interaction with biological targets.
Used in Material Science:
5-Iodo-2,3-dihydropyridazin-3-one may also be used in the development of new materials, such as organic semiconductors or catalysts, due to its aromatic and halogenated nature. Its properties could be harnessed to create materials with specific electronic or catalytic functions.
Used in Environmental Studies:
The environmental implications of 5-Iodo-2,3-dihydropyridazin-3-one, such as its potential toxicity or biodegradability, may be studied to understand its impact on ecosystems. This information could be crucial for the safe handling and disposal of the compound in industrial processes.
Used in Synthetic Chemistry:
5-Iodo-2,3-dihydropyridazin-3-one could be employed as a synthetic building block in the preparation of more complex molecules. Its reactivity and the presence of a halogen atom may facilitate various synthetic transformations, making it a valuable component in the synthesis of novel compounds.

InChI:InChI=1/C4H3IN2O/c5-3-1-4(8)7-6-2-3/h1-2H,(H,7,8)

Upstream product

• 932-22-9 4,5-dichloro-2H-pyridazin-3-one 
• 825633-93-0 2-benzyl-5-iodo-2,3-dihydropyridazin-3-one 

Downstream Products

• 847026-42-0 5-iodo-2-phenyl-2,3-dihydropyridazin-3-one 
• 825633-93-0 2-benzyl-5-iodo-2,3-dihydropyridazin-3-one 
• 1453852-63-5 (S)-2-(2-(tert-butyldimethylsilyloxy)-1-(4-chloro-3-fluorophenyl)ethyl)-5-iodopyridazin-3(2H)-one 
• 1243253-45-3 5-(4-chlorobenzylthio)pyridazin-3(2H)-one 
• 697739-27-8 4-[4-(trifluoromethyl)phenyl]-1H-pyridazin-6-one 
• 153239-91-9 5-iodo-2-methylpyridazin-3(2H)-one 

Relevant academic research and scientific papers

Synthesis and evaluation of 4- and 5-pyridazin-3-one phenoxypropylamine analogues as histamine-3 receptor antagonists

A novel series of 4-pyridazin-3-one and 5-pyridazin-3-one analogues were designed and synthesized as H3R antagonists. Structure-activity relationship revealed the 5-pyridazin-3-ones 8a and S-methyl 8b had excellent human and rat H3R affinities, and acceptable pharmacokinetic properties. In vivo evaluation of 8a showed potent activity in the rat dipsogenia model and robust wake-promoting activity in the rat EEG/EMG model.

PYRIDAZINONE GLUCOKINASE ACTIVATORS

Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of metabolic diseases and disorders such as, for example, type II diabetes mellitus.

SUBSTITUTED PYRIDAZINONE DERIVATIVES AS HISTAMINE-3 (H3) RECEPTOR LIGANDS

The present invention provides compounds according to Formulas I, II, III, IV, V, VI, VII or VIII; their use as H3 antagonists/inverse agonists, processes for their preparation, and pharmaceutical compositions thereof

DIAMINO-PYRIDINE, PYRIMIDINE, AND PYRIDAZINE MODULATORS OF THE HISTAMINE H4 RECEPTOR

Diamino-pyridine, pyrimidine and pyridazine compounds which may be used as H4 receptor modulators, and in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, such as allergy, asthma, autoimmune diseases, and pruritis.

Pyridizinone derivatives

The present invention provides compounds of formula (I*): their use as H3 inhibitors, processes for their preparation, and pharmaceutical compositions thereof.

Pyridazine derivatives. Part 39: Reactivity of 5-iodopyridazin-3(2H)-ones in palladium-catalysed reactions

In the search for novel antiplatelet agents, convenient and efficient methods for the preparation of 2,5-disubstituted pyridazin-3(2H)-ones are reported that utilise palladium-catalysed cross-coupling reactions. A post-coupling base-promoted isomerisation