825640-97-9Relevant academic research and scientific papers
Identification of a crucial amino acid in the helix position 6.51 of human tachykinin neurokinin 1 and 3 receptors contributing to the insurmountable mode of antagonism by dual NK1/NK3 antagonists
Bissantz, Caterina,Bohnert, Claudia,Hoffmann, Torsten,Marcuz, Anne,Schnider, Patrick,Malherbe, Pari
experimental part, p. 5061 - 5076 (2012/09/22)
The neurokinins are neuropeptides that elicit their effect through three GPCRs called NK1, NK2, and NK3. Compounds 5 and 6 are dual hNK1 (Ki of 0.7 and 0.3 nM) and hNK 3 (Ki of 2
DUAL NK1/NK3 ANTAGONISTS FOR TREATING SCHIZOPHRENIA
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Page 201, (2008/06/13)
The use of compounds of the general formula wherein the substituents are as described in claim 1 or pharmaceutically active acid-addition salts thereof for the preparation of medicaments for the treatment of schizophrenia.
