82583-95-7

Usage

Uses

Used in Pharmaceutical Industry:
2-Amino-5-methoxy-4-(phenylmethoxy)benzaldehyde is used as a chemical intermediate for the synthesis of various pharmaceutical compounds. Its unique molecular structure, which includes a benzaldehyde group, a methoxy group, a phenylmethoxy group, and an amino group, makes it a valuable building block in the development of new drugs.
Used in Chemical Research:
2-Amino-5-methoxy-4-(phenylmethoxy)benzaldehyde is used as a research compound in various scientific studies. Its complex molecular structure allows researchers to explore its potential applications and interactions with other molecules, which could lead to the discovery of new chemical reactions or the development of novel materials.
Used in Chemical Synthesis:
2-Amino-5-methoxy-4-(phenylmethoxy)benzaldehyde is used as a key component in the synthesis of other specialized chemicals. Its presence in the molecular structure of these compounds can impart unique properties or reactivity, making it an essential ingredient in the production process.
Note: The specific applications and industries mentioned above are based on the general properties of the compound and its potential uses. The actual applications may vary, and the detailed Material Safety Data Sheet (MSDS) should be consulted for accurate information on the compound's properties, uses, and safety measures.

InChI:InChI=1/C15H15NO3/c1-18-15-8-11(9-17)14(16)7-12(15)10-19-13-5-3-2-4-6-13/h2-9H,10,16H2,1H3

Upstream product

• 712-97-0 6-nitro-1,3-benzodioxole-5-carbaldehyde 
• 20194-18-7 sodium phenyl-methanolate 
• 82583-99-1 4-Benzyloxy-5-hydroxy-2-nitro-benzaldehyde 
• 2454-72-0 6-nitrovanillin 
• 2426-84-8 4-(benzyloxy)-5-methoxy-2-nitrobenzaldehyde 

Downstream Products

• 40705-22-4 4-benzyloxy-6-bromo-3-methoxybenzaldehyde 

Relevant academic research and scientific papers

Synthesis and in-vitro anti-hepatitis-B virus activity of 6H-[1]benzothiopyrano[4,3-b] quinolin-10-ols

A series of 9-methoxy-6H-[1]benzothiopyrano[4,3-b]quinolin-10-ols with a Mannich side chain were synthesized and evaluated for their anti-Hepatitis B virus (HBV) activity in HepG2.2.15 cells. Some compounds showed significant anti-HBV activity with IC50 values less than 41 μM. Among them, compound 9b was the most effective anti-HBV agent (IC50 = 1.7 μM, SI = 60.3).

Synthesis and anti-HBV activities evaluation of new ethyl 8-imidazolylmethyl-7-hydroxyquinoline-3-carboxylate derivatives in vitro

Some new ethyl 8-imidazolylmethyl-7-hydroxyquinoline-3-carboxylate derivatives have been synthesized and evaluated for their anti-hepatitis B virus (HBV) activities and cytotoxicities in HepG2.2.15 cells stable transfection with HBV. Compounds 13a, 11b, 11c, 12c, 13c, 11g, and 12g inhibited the expression of the viral antigens HBsAg or HBeAg in a low concentration, of which 11c (IC50 = 12.6 μM, SI = 12.4), 12c (IC50 = 3.5 μM, SI = 37.9), and 12g (IC50 = 2.6 μM, SI = 61.6) showed more active abilities to inhibit the replication of HBV DNA than the positive control lamivudine (3TC, IC50 = 343.2 μM, SI = 7.0).

Cleavage of the Methylenedioxy Ring. III. Cleavage with Sodium Benzyloxide in Dimethyl Sulfoxide

Cleavage of the methylenedioxy ring in aromatic formyl (1-3), nitro (4 and 5), and acetyl (30) compounds with N-sodium benzyloxide-benzyl alcohol in dimethyl sulfoxide gave 3-hydroxybenzene derivatives (19, 22-24, 26, 27, and 33).In the case of the acetyl compound 30, the 4-hydroxybenzene derivative (34) was also obtained as a minor product.Regioselective cleavage of the ring in aromatic compounds having electronwithdrawing groups with nucleophilic oxide anions is discussed.Cleavage of the ring in 1-5 and 30 with 2 N sodium methoxide in dimethyl sulfoxide-dimethylformamide was found to be useful for the practical preparation of 3-hydroxybenzene derivatives (6-10 and 31).Keywords - Cleavage of methylenedioxy ring; regioselectivity; piperonals; 3,4-methylenedioxy-nitrobenzene; 3,4-methylenedioxy-acetophenone; sodium methoxide; sodium phenoxide; sodium benzyloxide; dimethyl sulfoxide; dimethylformamide