82585-51-1

Basic information

• Product Name: 1H-Isoindole-1,3(2H)-dione, 2-[2-(4-chlorophenyl)-2-oxoethyl]-
• CAS NO: 82585-51-1
• Molecular Formula: C16H10ClNO3
• Molecular Weight: 299.713
• Mol File: 82585-51-1.mol

Chemical Properties

• CAS DataBase Reference: 1H-Isoindole-1,3(2H)-dione, 2-[2-(4-chlorophenyl)-2-oxoethyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Isoindole-1,3(2H)-dione, 2-[2-(4-chlorophenyl)-2-oxoethyl]-(82585-51-1)
• EPA Substance Registry System: 1H-Isoindole-1,3(2H)-dione, 2-[2-(4-chlorophenyl)-2-oxoethyl]-(82585-51-1)

Safety Data

• Hazardous Substances Data: 82585-51-1(Hazardous Substances Data)

Usage

Derivation

Synthetic derivative of glutamic acid

Initial purpose

Sedative and anti-inflammatory medication

Withdrawal from market

Caused severe birth defects

Potential uses

Treating conditions such as leprosy, multiple myeloma, and certain autoimmune diseases

Mechanism of action

Modulates the immune system and inhibits the production of inflammatory cytokines

Regulated use

Strictly regulated due to teratogenic effects

Side effects

Significant side effects including peripheral neuropathy and increased risk of blood clots.

Upstream product

• 156-41-2 4-chlorophenylethylamine 
• 706-07-0 1-chloro-4-(2-nitrovinyl)benzene 
• 104-88-1 4-chlorobenzaldehyde 
• 1074-82-4 potassium phtalimide 
• 536-38-9 4-chlorobenzoylmethyl bromide 

Downstream Products

• 130255-67-3 3,3-Bis(methylthio)-1-(p-chlorphenyl)-2-(N-phthalimido)-prop-2-en-1-on 
• 1607823-23-3 C₁₆H₉BrClNO₃ 
• 1607823-27-7 S-1-(1,3-dioxoisoindolin-2-yl)-2-(4-chlorophenyl)-2-oxoethyl O-ethyl carbonodithioate 
• 1607823-32-4 C₂₆H₂₆ClNO₆S₂ 
• 145949-83-3 N-<2-(4-chlorophenyl)prop-2-enyl>phthalimide 
• 127876-32-8 <2-(4-chlorophenyl)prop-2-enyl>amine 
• 1286255-68-2 4-bromo-N-[2-(4-chlorophenyl)allyl]benzamide 
• 1286255-73-9 (R)-2-(4-bromophenyl)-5-(chloromethyl)-5-(4-chlorophenyl)-4,5-dihydrooxazole 
• 113140-21-9 3-[3-(4-chloro-phenyl)-1H-pyrazol-4-ylamino]-but-2-enoic acid ethyl ester 
• 113140-22-0 3-(4-chloro-phenyl)-5-methyl-1H-pyrazolo[4,3-b]pyridin-7-ol 
• 113140-23-1 7-chloro-5-methyl-3-(4-chlorophenyl)-1H-pyrazolo[4,3-b]pyridine 
• 91857-91-9 3-(4-chloro-phenyl)-1H-pyrazol-4-ylamine 
• 216854-37-4 2-[5-(4-Chloro-phenyl)-1-methyl-1H-pyrazol-4-yl]-isoindole-1,3-dione 
• 216854-34-1 2-[3-(4-Chloro-phenyl)-1-methyl-1H-pyrazol-4-yl]-isoindole-1,3-dione 

Relevant articles and documents

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3-Nitro-2-phenylpropan-1-amine and 2-(4-chlorophenyl)-3-nitropropan-1-amine have been synthesized by the addition of nitrous acid to the corresponding trifluoroacetylaminomethylstyrenes followed by reduction of the double bond with sodium borohydride.A more general and efficient route involves the Michael addition of nitroalkane anions to methyl cinnamates followed by Curtius degradation of the corresponding acids. 2-(4-Chlorophenyl)-3-nitropropan-1-amine is a specific agonist of GABA and the GABAB receptor, with about half the activity of racemic baclofen at the isolated guinea pig ileum.Methylation or dimethylation at C3 decreases activity markedly.