82619-74-7

Upstream product

• 6010-25-9 1-(4-methoxyphenyl)-3-(2-thienyl)propen-1-one 
• 593-85-1 diguanidine carbonate 
• 123-11-5 4-methoxy-benzaldehyde 
• 50-01-1 guanidine hydrochloride 
• 6028-93-9 (2E)-3-(4-methoxyphenyl)-1-(thiophen-2-yl) prop-2-en-1-one 

Downstream Products

• 1630962-73-0 6-chloro-2-(4-methoxyphenyl)-8-methyl-4-(thiophen-2-yl)-4H-pyrimido[1,2-a]pyrimidine 
• 1630962-68-3 8-(4-methoxyphenyl)-2-methyl-N-phenyl-6-(thiophen-2-yl)-6H-pyrimido[1,2-a]pyrimidin-4-amine 
• 1630962-78-5 2-(4-methoxyphenyl)-8-methyl-4-(thiophen-2-yl)-4H-pyrimido[1,2-a]pyrimidin-6-ol 

Relevant academic research and scientific papers

Synthesis of thiophene-linked pyrimidopyrimidines as pharmaceutical leads

Thiophene-substituted chalcones were cyclised with guanidine in the presence of potassium hydroxide to get 4-substituted-6-thiophenopyrimidines 2a-e which were then refluxed with acetylacetone to obtain pyrimidopyrimidines 3a-e. Compounds 2a-e were also refluxed with ethylacetoacetate to afford pyirmidopyirimidines 4a-e which on refluxing with POCl3 in presence of DMF produced compounds 5a-e. Nucleophilic substitution reactions on 5a-e were carried out with aniline to obtain 6a-e. The structures of the newly synthesised compounds have been confirmed by elemental analysis and spectral studies. Some selected compounds have been screened for antibacterial and analgesic activities.