82625-24-9

Upstream product

• 100-83-4 meta-hydroxybenzaldehyde 
• 109-70-6 1.3-chlorobromopropane 
• 245510-06-9 3-(3-hydroxy-propoxy)-benzaldehyde 
• 98-88-4 benzoyl chloride 

Downstream Products

• 198271-58-8 3-[3-(4-methyl-piperazin-1-yl)-propoxy]-benzaldehyde 
• 123855-57-2 m-(3-chloropropyloxy)benzyl alcohol 
• 929683-25-0 2-(3-(3-chloropropoxy)benzylidene)-indan-1-one 
• 929683-26-1 2-[3-(3-imidazol-1-yl-propoxy)benzylidene]-indan-1-one 
• 1373134-00-9 3-[3-{4-(4-chlorobenzyl)piperazin-1-yl}propoxy]benzaldehyde 
• 1373134-01-0 3-[3-{4-(2-chlorobenzyl)piperazin-1-yl}propoxy]benzaldehyde 
• 1373134-04-3 3-[3-{4-(4-chlorobenzoyl)piperazin-1-yl}propoxy]benzaldehyde 
• 1373134-05-4 3-[3-{4-(2-chlorobenzoyl)piperazin-1-yl}propoxy]benzaldehyde 
• 1375149-67-9 16-[3-{3-(imidazol-1-yl)propoxy}benzylidene]-17-oxo-5-androsten-3β-yl acetate 
• 1375149-66-8 16-[3-{3-(imidazol-1-yl)propoxy}benzylidene]-5-androstene-3β,17β-diol diacetate 
• 1375149-65-7 16-[3-{3-(imidazol-1-yl)propoxy}benzylidene]-5-androstene-3β,17β-diol 
• 1321907-22-5 6-amino-5-{[3-(3-chloropropoxy)benzylidene]amino}-1,3-dimethylpyrimidine-2,4(1H,3H)-dione 
• 82625-27-2 (Z)-2-Benzo[d]isoxazol-3-yl-3-[3-(3-chloro-propoxy)-phenyl]-acrylonitrile 

Relevant academic research and scientific papers

HYPOXANTHINE COMPOUND

PROBLEM TO BE SOLVED: To provide a novel compound having an inhibitory action of prolyl hydroxylase (PHDs) and useful as a therapeutic agent of an inflammatory bowel disease such as ulcerative colitis. SOLUTION: The present invention relates to a hypoxanthine compound represented by the following formula (I) or a pharmacologically acceptable salt thereof. The compound of the present invention or its pharmaceutically acceptable salt has an inhibitory effect of prolyl hydroxylase and is useful as a therapeutic agent for inflammatory bowel disease such as ulcerative colitis. SELECTED DRAWING: None COPYRIGHT: (C)2021,JPOandINPIT

METHOD OF CONVERTING ALCOHOL TO HALIDE

The present invention relates to a method of converting an alcohol into a corresponding halide. This method comprises reacting the alcohol with an optionally substituted aromatic carboxylic acid halide in presence of an N-substituted formamide to replace a hydroxyl group of the alcohol by a halogen atom. The present invention also relates to a method of converting an alcohol into a corresponding substitution product. The second method comprises: (a) performing the method of the invention of converting an alcohol into the corresponding halide; and (b) reacting the corresponding halide with a nucleophile to convert the halide into the nucleophilic substitution product.

Synthesis and evaluation of meta substituted 1-(aryloxypropyl)-4- (chloroaryl) piperazines as potential atypical antipsychotics

A series of 1-(aryloxypropyl)-4-(chloroaryl) piperazines have been synthesized based upon their physicochemical similarity with respect to standard atypical antipsychotic drugs and their potential to cross the blood-brain barrier (log BB) as calculated by

NOVEL SERIES OF IMIDAZOLYL SUBSTITUTED STEROIDAL AND INDAN-1-ONE DERIVATIVES

The present invention provides a novel series of imidazolyl substituted steroidal and indan-1-one derivatives and salts thereof having the following general structural formulae (A and B)

Synthesis of a new series of 1H-imidazol-1-yl substituted 8-phenylxanthines as adenosine receptor ligands

A new series of 1H-imidazol-1-yl substituted 8-phenylxanthine analogs has been synthesized to study the effects of the imidazole group on the binding affinity of compounds for adenosine receptors. Competition binding studies of these compounds were carrie

NOVEL SERIES OF IMIDAZOLYL SUBSTITUTED STEROIDAL AND INDAN-1-ONE DERIVATIVES

The present invention provides a novel series of imidazolyl substituted steroidal and indan-1-one derivatives and salts thereof having the following general structural formulae (A and B)

Identification of 2-arylbenzimidazoles as potent human histamine H4 receptor ligands

A series of 2-arylbenzimidazoles was synthesized and found to bind with high affinity to the human histamine H4 receptor. Structure-activity relationships were investigated through library preparation and evaluation as well as traditional medicinal chemistry approaches, leading to the discovery of compounds with single-digit nanomolar affinity for the H4 receptor.

PHENOXYPROPYL DERIVATIVES

A phenoxypropyl derivative represented by the following formula STR1 wherein A represents a formyl group, a protected formyl group, a hydroxymethyl group, a protected hydroxymethyl group, or a halomethyl group, and Z represents a halogen atom, an amino gr

CHEMICAL INTERMEDIATES AND PROCESS

The present invention relates to novel intermediates of the formula STR1 wherein R 1 is hydrogen or lower alkyl and R is STR2--CH 2 OH or--CH 2 X in which X is a conventional leaving group and Y is lower alkyl and the use thereof in a process for the prep