82673-72-1Relevant academic research and scientific papers
5-{2-[4-(2-Methyl-5-quinolinyl)-1-piperazinyl]ethyl}-2(1H)-quinolinones and 3,4-dihydro-2(1H)-quinolinones: Dual-acting 5-HT1 receptor antagonists and serotonin reuptake inhibitors. Part 3
Bromidge, Steven M.,Arban, Roberto,Bertani, Barbara,Borriello, Manuela,Capelli, Anna-Maria,Di-Fabio, Romano,Faedo, Stefania,Gianotti, Massimo,Gordon, Laurie J.,Granci, Enrica,Pasquarello, Alessandra,Spada, Simone K.,Worby, Angela,Zonzini, Laura,Zucchelli, Valeria
supporting information; scheme or table, p. 7092 - 7096 (2011/01/03)
5-{2-[4-(2-Methyl-5-quinolinyl)-1-piperazinyl]ethyl}-2(1H)-quinolinones and 3,4-dihydro-2(1H)-quinolinones have been identified with different combinations of 5-HT1 autoreceptor antagonist and hSerT potencies and excellent rat PK profiles. The
Synthetic Application of Lithiation Reactions: A Convenient Synthesis of 3,4-Dihydro-5-hydroxycarbostyril, 1,2,3,4-Tetrahydro-5-hydroxy-2-oxo-1,7-naphthyridine, and Methyl 3-Methoxypyridine-4-carboxylate
Tamura, Yasumitsu,Chen, Ling Ching,Fujita, Masanobu,Kita, Yasuyuki
, p. 1257 - 1262 (2007/10/02)
3,4-Dihydro-5-hydroxycarbostyril (3), a key intermediate for a clinically used β-receptor blocking agent (1), and its 7-aza analog (4) were prepared by an acid-catalyzed cyclization of the N-pivaloylamino-esters (17 and 19), which were obtained by using o
