82690-96-8Relevant academic research and scientific papers
ASYMMETRIC SYNTHESIS OF AMINO ACIDS VIA THE CATALYTIC REDUCTION OF ACYLAMINOACRYLIC ACID AZLACTONE DERIVATIVES. 24. REDUCTIVE AMINOLYSIS OF 2-METHYL-4-BENZYLIDENE-Δ2-OXAZOLIN-5-ONE UPON TREATMENT WITH A CATALYTIC SYSTEM BASED ON S-PHENYLALANINE DERIVATIVES
Lyubeznova, M. R.,Karpeiskaya, E. I.,Klabunovskii, E. I.
, p. 720 - 726 (2007/10/02)
Reductive aminolysis of 2-methyl-4-benzylidene-Δ2-oxazolin-5-one upon treatment with a PdCl2-S-phenylalanine ester (dimethylamide) catalytic system leads to the formation of the corresponding acylated dipeptide derivatives, with the R,S-configuration (diastereomer) predominating (DE 9-27percent).The reaction stereoselectivity in dimethoxyethane increases sharply in the presence of triethylamine additive, and in the case of S-phenylalanine methyl ester reaches 47percent.The stepwise mechanism for this process has been studied.
Stereoselective Synthesis of Dipeptides by Asymmetric Reduction of Dehydropeptides Catalyzed by Chiral Rhodium Complexes
Meyer, Dominique,Poulin, Jean-Claude,Kagan, Henri B.,Levine-Pinto, Huguette,Morgat, Jean-Louis,Fromageot, Pierre
, p. 4680 - 4682 (2007/10/02)
Asymmetric catalysis was used to control the creation of an asymmetric center in a chiral dehydropeptide.The reduction of Ac-ΔPhe-(S)-Phe-OR (R=H or Me) was studied as a model.Depending on the type of chiral rhodium catalyst used, it was possible to selec
