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Usage

Properties & Specific Content of 1-cyclopent-1-enyl 4-fluorobenzene

The chemical formula of the compound consists of 11 carbon atoms, 11 hydrogen atoms, and 1 fluorine atom.
2. Fluoro-substituted cycloalkyl benzene derivative
The compound is a derivative of cycloalkyl benzene with a fluorine atom substitution, which affects its reactivity and properties.
3. Use in organic synthesis and pharmaceutical research
1-cyclopent-1-enyl 4-fluorobenzene serves as a building block for the synthesis of various biologically active molecules, making it valuable in the creation of new drugs and other chemical compounds.
4. Versatile chemical applications
The compound has potential applications in various industries, including pharmaceuticals, agrochemicals, and specialty chemical products.
5. Chemical structure and properties
The specific chemical structure and properties of 1-cyclopent-1-enyl 4-fluorobenzene make it suitable for use in the development of new drugs and other chemical compounds, as well as an intermediate in manufacturing processes.

Upstream product

• 460-00-4 1-Bromo-4-fluorobenzene 
• 132993-23-8 4-fluorophenyl trifluoromethanesulfonate 
• 142-29-0 cyclopentene 
• 183280-13-9 para-fluorophenyl pivalate 
• 120-92-3 cyclopentanone 
• 352-13-6 4-flourophenylmagnesium bromide 
• 827-87-2 1-(1-cyclopropylvinyl)-4-fluorobenzene 
• 459-45-0 4-fluorobenzenediazonium tetrafluoroborate 

Downstream Products

• 1014718-61-6 (±)-2-(4-fluorophenyl)cyclopentan-1-one 
• 793673-93-5 (-)-6-(4-fluorophenyl)tetrahydro-2H-pyran-2-one 
• 1356008-91-7 (10S,18R)-18-(4-fluorophenyl)-7-(3-methyl-1H-1,2,4-triazol-1-yl)-10,11,12,13,14,16,17,18-octahydro-15,2-(azeno)-8,4-(metheno)cyclopenta[h][1,6,10,12]oxatriazacycloheptadecin-11(3H)-ol 
• 1356010-70-2 (10R,18R)-18-(4-fluorophenyl)-7-(3-methyl-1H-1,2,4-triazol-1-yl)-10,11,12,13,14,16,17,18-octahydro-15,2-(azeno)-8,4-(metheno)cyclopenta[h][1,6,10,12]oxatriazacycloheptadecin-11(3H)-ol 
• 1356008-92-8 (10S,18S)-18-(4-fluorophenyl)-7-(3-methyl-1H-1,2,4-triazol-1-yl)-10,11,12,13,14,16,17,18-octahydro-15,2-(azeno)-8,4-(metheno)cyclopenta[h][1,6,10,12]oxatriazacycloheptadecin-11(3H)-ol 
• 1356010-69-9 (10R,18S)-18-(4-fluorophenyl)-7-(3-methyl-1H-1,2,4-triazol-1-yl)-10,11,12,13,14,16,17,18-octahydro-15,2-(azeno)-8,4-(metheno)cyclopenta[h][1,6,10,12]oxatriazacycloheptadecin-11(3H)-ol 
• 1356008-90-6 18-(4-fluorophenyl)-7-(3-methyl-1H-1,2,4-triazol-1-yl)-10,11,12,13,14,16,17,18-octahydro-15,2-(azeno)-8,4-(metheno)cyclopenta[h][1,6,10,12]oxatriazacycloheptadecin-11(3H)-ol trifluoroacetate 
• 1356008-80-4 (11Z)-7-cyano-18-(4-fluorophenyl)-18-methyl-10,13,14,16,17,18-hexahydro-15,2-(azeno)-8,4-(metheno)cyclopenta[h][1,6,10,12]oxatriazacycloheptadecine trifluoroacetate 
• 1356008-82-6 (11E)-7-cyano-18-(4-fluorophenyl)-18-methyl-10,13,14,16,17,18-hexahydro-15,2-(azeno)-8,4-(metheno)cyclopenta[h][1,6,10,12]oxatriazacycloheptadecine trifluoroacetate 
• 1356008-78-0 18-(4-fluorophenyl)-3,11,12,13,14,16,17,18-octahydro-10H-2,15-(azeno)-4,8-(metheno)cyciopenta[h][1,4,10,12]oxatriazacycloheptadecine-7-carbonitrile 
• 1356008-39-3 (R)-19-(4-fluorophenyl)-7-(3-methyl-1H-1,2,4-triazol-1-yl)-11,12,13,14,15,17,18,19-octahydro-10H-16,2-(azeno)-8,4-(metheno)cyclopenta[i][1,4,7,11,13]oxatetraazacyclooctadecine 
• 1356008-40-6 (S)-19-(4-fluorophenyl)-7-(3-methyl-1H-1,2,4-triazol-1-yl)-11,12,13,14,15,17,18,19-octahydro-10H-16,2-(azeno)-8,4-(metheno)cyclopenta[i][1,4,7,11,13]oxatetraazacyclooctadecine 
• 1356007-28-7 (R)-7-cyano-19-(4-fluorophenyl)-12-methyl-11,12,13,14,15,17,18,19-octahydro-10H-16,2-(azeno)-8,4-(metheno)cyclopenta[i][1,4,7,11,13]oxatetraazacyclooctadecine 

Relevant academic research and scientific papers

Nickel-catalyzed Heck reaction of cycloalkenes using aryl sulfonates and pivalates

Nickel-catalyzed Heck reaction of cycloalkenes delivers unusual conjugated arylated isomers. Nickel(0) catalysts ligated by chelating dialkylphosphines effectively activate not only aryl triflates as electrophiles, but also less reactive aryl mesylates, t

Regio- and enantioselective Baeyer-Villiger oxidation: Kinetic resolution of racemic 2-substituted cyclopentanones

A kinetic resolution of racemic 2-substituted cyclopentanones via highly regio- and enantioselective Baeyer-Villiger oxidation has been successfully developed. The reaction could afford the normal 6-substituted δ-lactones in up to 98% ee and >19/1 regioselectivity. Meanwhile, the unreacted ketones were recovered in excellent ee values (up to 98%). It represents the best results of the kinetic resolution of racemic 2-substituted cyclopentanones via nonenzymic asymmetric BV oxidation.

COMPOUNDS FOR THE REDUCTION OF BETA-AMYLOID PRODUCTION

Compounds of the formula (I) are provided, including pharmaceutically acceptable salts thereof: which modulate β-amyloid peptide (β-AP) production, and are useful in the treatment of Alzheimer's Disease and other conditions affected by -amyloid peptide (β-AP) production.

COMPOUNDS FOR THE REDUCTION OF β-AMYLOID PRODUCTION

The present disclosure provides a series of compounds of the formula (I), which modulate β-amyloid peptide (β-ΑΡ) production and are useful in the treatment of Alzheimer's Disease and other conditions affected by β-amyloid peptide (β-ΑΡ) production.

COMPOUNDS FOR THE REDUCTION OF β-AMYLOID PRODUCTION

The present disclosure provides a series of compounds of the formula (I) which modulate β-amyloid peptide (β-AP) production and are useful in the treatment of Alzheimer's Disease and other conditions affected by β-amyloid peptide (β-AP) production.

Role of the hydrogen bonding heteroatom-lys53 interaction between the p38r mitogen-activated protein (map) kinase and pyridinyl-substituted 5-membered heterocyclic ring inhibitors

In the framework of investigating the role of heteroatoms in pyridinyl-substituted 5-membered (hetero)cycles as potential p38α MAP kinase inhibitor scaffolds, cyclopentene, pyrrole, furan, and imidazole analogues were synthesized and tested with respect t

A convenient synthesis of 1-(4-fluorophenyl)-2-(4-pyridyl)cyclopentene from cyclopentanone

In the framework of investigating the role of pyridyl-substituted five-membered heterocycles as potential p38 mitogen-activated protein kinase inhibitors, we synthesized the disubstituted carbocyclic analogue, 1-(4-fluorophenyl)-2-(4-pyridyl)cyclopentene. A multistep synthesis of this compound starting from cyclopentanone is reported. Cyclopentanone was converted into 1-cyclopentenyl-4-fluorobenzene using a Grignard reaction. The oxidation of this product with hydrogen peroxide and formic acid gave 2-(4-fluorophenyl) cyclopentanone. This ketone was activated using a neodymium salt (NdCl 3·2LiCl) and subsequently reacted with a complexed Grignard reagent (pyMgCl·LiCl) to give the corresponding cyclopentanol derivative. Finally, dehydration of the latter alcohol led to the title compound. Georg Thieme Verlag Stuttgart.

REACTION OF DIAZONIUM SALTS WITH TRANSITION METALS-III. PALLADIUM(0)-CATALYZED ARYLATION OF UNSATURATED COMPOUNDS WITH ARENEDIAZONIUM SALTS

Palladium (0) catalyzed reactions of arenediazonium salts for arylation of aliphatic and cyclic olefins and allylic alcohols, styrene and ethyl acrylate were studied.Effect of the olefinic compounds and other reaction variables on the arylation were presented.Arylpalladium species was proposed as the most plausible intermediated in this reaction.