827017-66-3Relevant academic research and scientific papers
Total synthesis and biological evaluation of a series of macrocyclic hybrids and analogues of the antimitotic natural products dictyostatin, discodermolide, and taxol
Paterson, Ian,Naylor, Guy J.,Gardner, Nicola M.,Guzman, Esther,Wright, Amy E.
scheme or table, p. 459 - 473 (2011/10/12)
The design, synthesis, and biological evaluation of a series of hybrids and analogues of the microtubule-stabilizing anticancer agents dictyostatin, discodermolide, and taxol is described. A 22-membered macrolide scaffold was prepared by adapting earlier
Design, synthesis and biological evaluation of a macrocyclic discodermolide/dictyostatin hybrid
Paterson, Ian,Gardner, Nicola M.
, p. 49 - 51 (2007/10/03)
A 22-membered macrocyclic discodermolide/dictyostatin hybrid has been designed and synthesised; biological evaluation against a range of human cancer cell lines revealed significant levels of growth inhibition. The Royal Society of Chemistry.
Development of a third-generation total synthesis of (+)-discodermolide: An expedient Still-Gennari-type fragment coupling utilizing an advanced β-ketophosphonate
Paterson, Ian,Lyothier, Isabelle
, p. 5494 - 5507 (2008/04/18)
A novel total synthesis of the complex polyketide discodermolide, a promising anticancer agent of marine sponge origin, has been completed in 11.1% overall yield over 21 linear steps. This third-generation approach features an unprecedented Still-Gennari-
