827017-81-2Relevant academic research and scientific papers
Development of a third-generation total synthesis of (+)-discodermolide: An expedient Still-Gennari-type fragment coupling utilizing an advanced β-ketophosphonate
Paterson, Ian,Lyothier, Isabelle
, p. 5494 - 5507 (2008/04/18)
A novel total synthesis of the complex polyketide discodermolide, a promising anticancer agent of marine sponge origin, has been completed in 11.1% overall yield over 21 linear steps. This third-generation approach features an unprecedented Still-Gennari-
Total synthesis of (+)-discodermolide: An improved endgame exploiting a Still-Gennari-type olefination with a C1-C8 β-ketophosphonate fragment
Paterson, Ian,Lyothier, Isabelle
, p. 4933 - 4936 (2007/10/03)
(Chemical Equation Presented) An improved, third-generation, total synthesis of (+)-discodermolide, a potent microtubule-stabilizing anticancer agent of marine sponge origin, is achieved in 11.1% yield over 21 steps. Key steps include a Still-Gennari HWE
