82704-14-1Relevant articles and documents
Preparation of labeled aromatic amino acids: Via late-stage18F-fluorination of chiral nickel and copper complexes
Craig, Austin,Kolks, Niklas,Urusova, Elizaveta A.,Zischler, Johannes,Brugger, Melanie,Endepols, Heike,Neumaier, Bernd,Zlatopolskiy, Boris D.
, p. 9505 - 9508 (2020/09/03)
A general protocol for the preparation of 18F-labeled AAAs and α-methyl-AAAs applying alcohol-enhanced Cu-mediated radiofluorination of Bpin-substituted chiral complexes using Ni/Cu-BPX templates as double protecting groups is reported. The chiral auxiliaries are easily accessible from commercially available starting materials in a few synthetic steps. The versatility of the method was demonstrated by the high-yielding preparation of a series of [18F]F-AAAs and the successful implementation of the protocol into automated radiosynthesis modules. This journal is
ASYMMETRIC SYNTHESIS OF THREONINE AND RETRORACEMIZATION OF AMINO ACIDS USING Ni(II) COMPLEXES OF SCHIFF BASES WITH S-2-N-(N'-BENZYLPROLYL)AMINOBENZALDEHYDE
Belokon', Yu. N.,Chernoglazova, N. I.,Kochetkov, K. A.,Garbalinskaya, N. S.,Ryzhov, M. G.,et al.
, p. 738 - 746 (2007/10/02)
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(S)-o-N-(N-Benzylprolyl)aminobenzaldehyde and (S)-o-N-(N-Benzylprolyl)aminoacetophenone as Reagents for Asymmetric Synthesis of Threonine
Belokon, Yuuri N.,Zeltzer, Irina E.,Ryzhov, Michail G.,Saporovskaya, Marina B.,Bakhmutov, Vladimir I.,Belikov, Vasili M.
, p. 180 - 181 (2007/10/02)
Chiral aldehydes and ketones, derivatives of proline and piperidine-2-carboxylic acid have been synthesized and their Schiff bases with glycine form copper complexes which were hydroxyethylated with acetaldehyde; decomposition of the complexes obtained gave threonine with an optical purity of up to 97-100percent and with threo/allo ratios of up to 19 : 1, and the chiral reagents can be recovered and reused with no loss of optical purity of the threonine.
