82770-40-9Relevant academic research and scientific papers
HEPATITIS C INHIBITOR COMPOUNDS
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Page/Page column 29-30, (2012/05/04)
Compounds of Formula (I) and (II) wherein R1, R2, R3, R6, A and A' are defined herein. The compounds are useful as inhibitors of the function of NS5A protein encoded by HCV for the treatment of hepatitis C viral infection.
Enantiodivergent biosynthesis of the dimeric sphingolipid oceanapiside from the marine sponge Oceanapia phillipensis. Determination of remote stereochemistry
Nicholas, Gillian M.,Molinski, Tadeusz F.
, p. 4011 - 4019 (2007/10/03)
The absolute stereochemistry of oceanapiside, an antifungal α,ω-bis- aminohydroxylipid with four stereogenic centers from the marine sponge Oceanapia phillipensis Dendy, 1895, has been obtained as 2S,3R,26R,27R from development and application of a general CD method based on superposition of additive exciton couplings in perbenzoyl derivatives of bis-amino alcohols. The method allows simultaneous determination of the local relative configuration at each of the termini of the long chain bis-aminolipid and also relates the absolute configuration of the two remote termini. Oceanapiside contains erythro and threo relative configurations at C1,2 and C26,27, respectively, but opposite absolute configurations at the amino substituted carbons C2 and C27 which implies an enantiodivergent biogenesis formally derived from both D- and L-amino acids.
