82787-85-7Relevant academic research and scientific papers
Heterocyclic thromboxane synthetase inhibitors and pharmaceutical compositions containing them
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, (2008/06/13)
Heterocyclic thromboxane synthetase inhibitors of the formula STR1 wherein R1, which is attached to the 2-, 3- or 4-position, is hydrogen, halogen, C1 -C4 alkyl, hydroxy or C1 -C4 alkoxy; Y, which is attached to the 2- or 3-position, is --COOH, --COO(C1 -C4 alkyl) or --CONH2 ; X is O, S, NH, N(C1 -C4 alkyl) or N(benzyl); and R, which is attached to the 5-, 6- or 7-position, is a group of the formula STR2 or (3- or 4-pyridyl)-Z2 - wherein Z1 is --CH2 --, --CH2 CH2 -- or --CH2 CH2 O-- and Z2 is --CH2 --, --CH2 CH2 --, --CH=CH--, --CH2 O-- or --OCH2 --; and their pharmaceutically acceptable salts; processes for their preparation, and pharmaceutical compositions containing them.
