82789-32-0

Basic information

• Product Name: 1-(4-Methylphenyl)-1,2,3,4-tetrahydro-3-carbomethoxy-β-carboline
• Synonyms: 1-(4-Methylphenyl)-1,2,3,4-tetrahydro-3-carbomethoxy-β-carboline
• CAS NO: 82789-32-0
• Molecular Weight: 320.391
• Mol File: 82789-32-0.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 1-(4-Methylphenyl)-1,2,3,4-tetrahydro-3-carbomethoxy-β-carboline(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-Methylphenyl)-1,2,3,4-tetrahydro-3-carbomethoxy-β-carboline(82789-32-0)
• EPA Substance Registry System: 1-(4-Methylphenyl)-1,2,3,4-tetrahydro-3-carbomethoxy-β-carboline(82789-32-0)

Safety Data

• Hazardous Substances Data: 82789-32-0(Hazardous Substances Data)

Upstream product

• 82789-23-9 C₁₉H₁₈N₂O₂ 
• 73-22-3 L-Tryptophan 
• 67-56-1 methanol 
• 54-12-6 Trp 
• 104-87-0 4-methyl-benzaldehyde 
• 4299-70-1 L-tryptophan methyl ester 
• 7524-52-9 (S)-tryptophan methyl ester hydrochloride 
• 7303-49-3 DL-tryptophan methyl ester 

Downstream Products

• 204717-44-2 methyl 1-( p-tolyl)-9H-pyrido[3,4-b]indole-3-carboxylate 

Relevant articles and documents

Novel β-carboline-based indole-4,7-quinone derivatives as NAD(P)H: Quinone-oxidoreductase-1 inhibitor with potent antitumor activities by inducing reactive oxygen species, apoptosis, and DNA damage

Eighteen new β-carboline-based indole-4,7-quinone derivatives (12a–i and 13a–i) were designed and synthesized, and their in vitro and in vivo antiproliferative activities were studied. Most of target compounds showed strong inhibition on three human tumor cells' proliferation. In particular, the most active compound 13g not only displayed more prominent antiproliferative activities than β-lapachone, a clinical antitumor candidate, but also exerted significant NAD(P)H: quinone-oxidoreductase-1 (NQO1) inhibitory activity and NQO1-dependent cytotoxicity in HT29 cells. Furthermore, 13g dose-dependently induced high ROS levels in HT29 cells, and selectively inhibited cancer cell but not non-tumor colon cell proliferation in vitro. Importantly, 13g promoted HT29 cell apoptosis and DNA damage by regulating relative apoptotic proteins and H2AX expression. Finally, 13g displayed significant growth inhibition of HT29 human colorectal adenocarcinoma xenograft in mice without overt toxicity.

Syntheses of new substituted triazino tetrahydroisoquinolines and β-carbolines as novel antileishmanial agents

A series of triazino tetrahydroisoquinolines (3-5) and β-carboline derivatives (15-27) have been synthesized as novel antileishmanial agents. Among them, compounds 15, 16 and 25 have shown 78.0%, 78.6% and 68.0% in vivo inhibition against Leishmania donov

Potent 1,3-disubstituted-9H-pyrido[3,4-b]indoles as new lead compounds in antifilarial chemotherapy

Substituted 9H-pyrido[3,4-b]indoles (β-carbolines), identified in our laboratory as potential pharmacophores for designing macrofilaricidal agents, have been explored further for identifying the pharmacophore responsible for the high order of adulticidal