828267-45-4

Basic information

• Product Name: 4-Fluoro-7-Methyl-2,3-dihydro-1H-inden-1-one
• Synonyms: 4-Fluoro-7-Methyl-2,3-dihydro-1H-inden-1-one;4-fluoro-7-Methyl-2,3-dihydroinden-1-one
• CAS NO: 828267-45-4
• Molecular Formula: C10H9FO
• Molecular Weight: 164.1762632
• Mol File: 828267-45-4.mol

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-Fluoro-7-Methyl-2,3-dihydro-1H-inden-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Fluoro-7-Methyl-2,3-dihydro-1H-inden-1-one(828267-45-4)
• EPA Substance Registry System: 4-Fluoro-7-Methyl-2,3-dihydro-1H-inden-1-one(828267-45-4)

Safety Data

• Hazardous Substances Data: 828267-45-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research:
4-Fluoro-7-Methyl-2,3-dihydro-1H-inden-1-one is used as a research compound for its potential antiviral and anticancer activities. Its unique structure and properties make it a valuable candidate for the development of new therapeutic agents.
Used in Organic Synthesis:
In the field of organic synthesis, 4-Fluoro-7-Methyl-2,3-dihydro-1H-inden-1-one serves as a key intermediate or building block for the synthesis of other bioactive compounds. Its versatility in chemical reactions allows for the creation of a variety of new molecules with potential applications in medicine and other industries.
Used in Drug Development:
4-Fluoro-7-Methyl-2,3-dihydro-1H-inden-1-one is used as a starting material in drug development, where its chemical properties can be further modified to enhance its therapeutic effects or to improve its pharmacokinetic and pharmacodynamic profiles.
Used in Chemical Research:
In the realm of chemical research, 4-Fluoro-7-Methyl-2,3-dihydro-1H-inden-1-one is employed to study the reactivity and selectivity of various chemical reactions, contributing to the understanding of reaction mechanisms and the development of new synthetic methodologies.
Overall, 4-Fluoro-7-Methyl-2,3-dihydro-1H-inden-1-one is a versatile chemical compound with significant applications in various fields, particularly in pharmaceutical research and organic synthesis, where its unique properties and potential for medicinal applications are being extensively explored.

Upstream product

• 50-00-0 formaldehyd 
• 33184-16-6 5-fluoro-2-methylbenzoic acid 
• 108-59-8 malonic acid dimethyl ester 

Relevant articles and documents

Rh-Catalyzed Annulation of Benzoic Acids, Formaldehyde, and Malonates via ortho-Hydroarylation to Indanones

A three-component reaction from readily available low-cost materials of benzoic acids, formaldehyde, and malonates for the preparation of indanones by rhodium catalysis is reported. The annulation is initiated by an ortho-hydroarylation of benzoic acids, and a Lewis acid is not required. The solvent has a significant influence to the reaction, and 2-substituted or nonsubstituted indanones are obtained by the change of solvent.

CYCLIC AMINE DERIVATIVE OR SALT THEREOF

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Microwave-enhanced carbonylative generation of indanones and 3-acylaminoindanones

(Chemical Equation Presented). The development of microwave-accelerated protocols for palladium(0)-catalyzed carbonylative cyclization of unsaturated aryl bromides and chlorides is described. By employing o-bromostyryl derivatives lacking substituents on the vinylic bond, molybdenum hexacarbonyl-mediated in situ carbonylation delivered a set of indan-1-one products in high yield after only 20 min of heating. Without the addition of the tri-tert-butylphosphine releasing Fu-salt ((t-Bu)3PHBF4), only incomplete conversions of sluggish o-styryl bromides and chlorides were realized. Internal and chemoselective palladium(0)-catalyzed Heck arylations of enamides afforded suitable starting materials for subsequent rapid ring-closing reactions. Microwave-heated intramolecular in situ carbonylation of these electron-rich and sterically congested olefins conveniently afforded eight functionalized 3-acylaminoindanone derivatives in a novel synthetic process. Attempted carbonylative annulation of electron-poor o-bromocinnamic acid derivatives furnished only the corresponding lactones via a competing hydroxycarbonylation- Michael addition reaction sequence.